A brief scene from the 1936 Charlie Chaplin classic Modern Times where he accidentally eats cocaine hidden in a salt shaker by a fellow jail inmate.
The smuggled “nose powder” makes Chaplin go a bit strange and causes him to accidentally prevent a jailbreak, making him a hero.
In fact, the episode is a central plot device in the film, presumably before such comical treatment of drug use became politically incorrect.
Link to cocaine scene from Modern Times (via Fluxo Do Pensamento).
Mind Hacks 
Douglas Fairbanks’ 1916 The Mystery of the Leaping Fish has to be seen to be believed.