A poem from the book Uncut Confetti by the brilliant John Hegley:
For Therapeutic Purposes
I have not been quite right in the head
Like a balding tyre, I’ve been losing my grip
I have been given various medications
to help me cope
anti-depressants
anti-psychotics
And my brother has given me
a skipping rope.
Hegley’s poems move effortlessly between the comic and the achingly poignant, and often touch upon the more curious aspects of human nature.
The New York Times is reporting that James Watson, co-discover of DNA, will have the whole of his DNA sequence made publicly available, with the exception of one gene known as apolipoprotein E.
Watson doesn’t want to know which version of the gene he has, as it is one of the strongest predictors for the development of Alzheimer’s disease.
In fact, it’s the only gene which has specifically been shown to increase risk for the brain disorder.
The gene for apolipoprotein E, or ApoE as it is more widely known, comes in three main forms or alleles called ApoE ε2, ε3 and ε4.
Studies have consistently shown that the more ApoE Œµ4 alleles you have, the higher the chances of developing Alzheimer’s disease and the younger the age it will begin to take effect.
In fact, having two ApoE Œµ4 alleles virtually guarantees you’ll have Alzheimer’s by the age of 80 and if you do get Alzheimer’s disease, the presence of this allele seems to make it more likely that you’ll experience delusions and psychosis.
The gene codes for the apolipoprotein which combines with fats (such as cholesterol) in the body and transports them to various places, including the liver, where they are broken down.
Alzheimer’s disease is linked to the accumulation of ‘amyloid plaques’ and ‘neurofibrillary tangles’ in the brain, both of which are abnormal clumps of protein.
The presence of the ApoE ε4 allele makes these protein clumps more likely, even in people who have not developed the disorder.
However, the exact link between ApoE and fat processing, protein clumps and Alzheimer’s disease is still not fully understood.
What Watson does understand, however, is that he could work out how likely he is to develop Alzheimer’s disease from the versions of the gene he carries, and it seems he’d rather not live with the knowledge.
This is not an uncommon situation, as people with genetic disorders, or people whose close family have genetic disorders, often have to decide whether they want to know the chances of them or their children developing a potentially life-threatening disease.
Genetic counselling is a service that assists the the person in understanding the risks and possible outcomes based on the science of genetics, as well as dealing with the emotional impact of the sometimes difficult process of discovery and decision-making.
Link to NYT article ‘Genome of DNA Discoverer Is Deciphered’.
The San Francisco Chronicle has an article on neurotech industry consultant Zack Lynch, who you might know from the blog Brain Waves.
Lynch is executive director of the Neurotechnology Industry Organization, an umbrella organisation for the commercial neuroscience sector, and managing director of NeuroInsights, a business intelligence service.
The San Francisco Chronicle article looks at Lynch’s aims and work, in partnership with his wife, neurobiologist Casey Lynch, as well as giving an insight into how the neurotech industry is becoming an increasingly important force in the marketplace and in policy making.
Lynch is an interesting guy to watch. He’ll always pitch for industry, but his job relies on him having a balanced view of what’s likely to work out in the marketplace.
Interestingly, the article also notes he’s written a book on the neurotech industry that’s recently found a publisher:
The first neurotechnology project Lynch took on in 2001, a book titled “Brain Waves,” just landed a publisher. The book allows Lynch to take his favored “200-year view,” speculating on how business, politics and culture will evolve in a future era of neurotech inventions that might change the way people think and communicate. Lynch is fascinated by the ethical and social dilemmas that might emerge. If drugs can enhance memory, for example, would college entrance exams still be fair? “Who’s going to be able to afford this?” Lynch asks.
Link to article ‘Brainstorming about the brain’.
The latest edition of Scientific American Mind has just been published, and as is customary, two of the feature articles are freely available online.
The first is on the psychology of teams and how science is attempting to understand what makes a successful and productive working party.
The article describes effective team learning strategies and how emotions help groups bond during work.
These researchers trained college students to assemble transistor radios either alone or in groups of three. A week later the subjects were tested with their original group or, for people who received solo training, in newly formed groups. Members of groups that had trained together remembered more details, built better-quality radios and showed greater trust in fellow members’ expertise. People in newly formed groups were less likely to have the right mix of skills to complete the task efficiently and knew less about one another’s strengths.
The second article looks at the controversial topic of prescribing psychiatric drugs to children and evidence that the use of psychiatric drugs alters the growing brain.
This is weighed up against the evidence that in children with serious mental illness, an untreated disorder may alter the growing brain.
It’s a difficult topic because it often boils down to picking the lesser of two evils, although, because of lack of research, it’s often not easy to tell which will have the least negative effect for any given child.
It’s a fascinating article on one of the major issues facing psychiatry today.
There are also articles on expertise and the role of mirror neurons in stroke recovery in the full edition, as well as all the regular features.
Link to article ‘The Science of Team Success’.
Link to article ‘Kids on Meds — Trouble Ahead’.
Polymath physician Dr Ray Tallis has written an optimistic article in the latest edition of Philosophy Now magazine arguing that human technological enhancement is over-hyped but no reason for fear.
Tallis is a professor of geriatric medicine, so it’s no surprise that he sees some of the most applicable benefits of technological advances for diseases like Alzheimer’s and Parkinson’s.
Critics have suggested that using technology to enhance human abilities, whether by drugs, implants or genetics, will lead to an erosion of our sense of identity.
Tallis looks back on past promises and argues that this is unlikely to be the case:
The most often repeated claim is that we are on the verge of technological breakthroughs – in genetic engineering, in pharmacotherapy and in the replacement of biological tissues (either by cultured tissues or by electronic prostheses) – which will dramatically transform our sense of what we are and will thereby threaten our humanity. A little bit of history may be all that is necessary to pour cooling water on fevered imaginations.
In 1960, leading computer scientists, headed by the mighty Marvin Minsky, predicted that by 1990 we would have developed computers so smart that they would not even treat us with the respect due to household pets. Our status would be consequently diminished. Anyone seen any of those? Smart drugs that would transform our consciousness have been expected for 50 years, but nothing yet has matched the impact of alcohol, peyote, cocaine, opiates, or amphetamines, which have been round a rather long time.
As well as making some telling philosophical points, the article is quite funny in places, as Tallis uses some of his literary skills to good effect.
Link to Philosophy Now article ‘Enhancing Humanity’.
American TV discussion host Charlie Rose has a series of programmes available online where some of the world’s leading researchers discuss Freud, neurobiology and the latest in psychological treatments for mental illness.
The first programme is a discussion of the legacy of Freud, with neurobiologist Eric Kandel, Freudian psychotherapist Peter Fonagy, inventor of cognitive therapy Aaron Beck and psychiatrist Charlie Roose.
It is a great guide to the differences between Freudian and cognitive approaches to psychotherapy, as well as how it relates to brain function and modern neuroscience.
A second programme looks at a similar topic, but expands the discussion to include cognitive psychological research and also includes psychologists Nancy Kanwisher, Nora Volkow, Rebecca Saxe and Liz Phelps.
Finally, one is a special interview with Eric Kandel, which is guest hosted by fellow Novel Prize winner Harold Varmus, who, incidentally co-founded PLoS – the organisation behind some of the world’s finest open-access science journals.
Quick links from the past week in mind and brain news:
A disquieting feeling of strangeness?: Just found this great 2001 paper on the ‘the art of the mentally ill’ on PubMedCentral.
Brain scan can predict response to antidepressants, reports New Scientist.
Neurophilosophy has an excellent article on famous amnesia case HM.
Pesticides ‘up Parkinson’s risk‘ according to BBC News.
Scientific American reports that Scottish scientists uncover a striking link between genes for brain size and tonality in spoken language.
Developing Intelligence investigates the neuroscience of imagination.
Forbes profile a cognitive scientist. Still no word from Hello magazine.
The rate of diagnosed clinical depression among retired American football players is strongly correlated with the number of concussions they sustained, reports The New York Times.
Pure Pedantry looks at research on storing computer information in biological neurons.
Young children can crudely add and subtract numbers before they have learned the rules of arithmetic, reports Scientific American.
Brain Ethics highlight a new book by the widely liked and respected neuroscientist, Chris Frith.
The BPS Research Digest covers a simple yet fascinating study on the power on lightly touching someone’s arm when trying to persuade them.
In this case, the psychology study involved a man asking women to dance or for their phone numbers.
A good-looking man approached 120 women in a night club over a period of three weeks, and asked them to dance. It was in the name of science – the man was an assistant to the psychologist Nicolas Guegen. Remarkably, of the 60 women who he touched lightly on the arm, 65 per cent agreed to a dance, compared with just 43 per cent of the 60 women who he asked without making any physical contact.
A second study involved three male research assistants approaching 240 women in the street and asking them for their phone numbers. Among those 120 women who the researchers touched lightly on the arm, 19 per cent agreed to share their number, compared with 10 per cent of the women with whom no physical contact was made.
Christian has a fantastic talent for finding really intriguing studies and this is a particularly good example.
Have a look at his article for more on why this effect might occur.
Link to BPSRD on ‘The power of a light touch on the arm’.
An article in Time magazine discusses how an understanding of the psychology of disgust is being applied to selling products and the arrangement of items in supermarkets.
One key finding has been that disgust is heavily linked to ideas of contamination and this holds even when there’s no risk – just the idea is enough.
For example, people are less likely to want to put a plastic spoon in their mouth that has touched fake plastic vomit, despite the fact that it is no more risky than putting a spoon in your mouth that has touched other plastic spoons in the packet.
Psychologists Andrea Morales and Gavan Fitzsimons has discovered that this principle applies to consumer products that are linked to things that can trigger disgust – rubbish bags, nappies, toilet paper and so on.
Crucially, the contamination principal works here, so people view things less favourably that have been near these products.
Strong preferences were just what the subjects exhibited. Any food that touched something perceived to be disgusting became immediately less desirable itself, though all of the products were in their original wrapping. The appeal of the food fell even if the two products were merely close together; an inch seemed to be the critical distance. “It makes no sense if you think about it,” says Fitzsimons. More irrationally still, the subjects were less comfortable with a transparent package than an opaque one, as if it somehow had greater power to leak contamination. Whatever the severity of the taint, the result was predictable…
“More and more stores organize products by category,” says Morales, “so you have a baby aisle, for example, with diapers and wipes and baby food all together.” Supermarkets might want to rethink that arrangement.
Link to Time article ‘The Science of Disgust’.
In a study investigating how the brain generates paranormal experiences and psychotic states, researchers used strong electromagnets to alter brain function and found they could reduce the number of times healthy volunteers saw spontaneously experienced false perceptions.
The researchers altered the function of the temporal lobes with a method called transcranial magnetic stimulation or TMS while participants were asked to detect supposedly ‘hidden’ images in what were actually completely random dot patterns.
When compared to a control area at the top of the head, reducing left temporal lobe function significantly reduced the number of false perceptions.
During the procedure, participants were asked to look at a series of quickly presented dot patterns and told to indicate which had images ‘hidden’ within them.
Crucially, they were told not to guess and only to press a button when they genuinely detected a ‘hidden’ image. In actual fact, all the dot patterns were completely random and none contained ‘hidden’ images, so every ‘detect’ response was a false perception of meaningful information.
Just before each dot pattern was presented, the brain was stimulated with a pulse of TMS, either to the left or right temporal lobe, or a control spot at the top of the head known as the vertex.
TMS uses magnetic pulses to safely ‘switch off’ a small area of brain for a several hundred milliseconds.
When compared to the control area, temporarily ‘switching off’ an area on the left temporal lobe significantly reduced the number of false perceptions, suggesting that this brain area is likely to be involved in making meaningful connections, even when there’s no meaning to be found.
Seeing meaningful information in random data is known as ‘apophenia’ and statistically is known as a false positive or a Type I error.
Previous research has shown that this tendency is known to be enhanced in people who report high levels of paranormal experience, and to a greater extent, in people who experience psychosis – the mental state involving delusions and / or hallucinations that is most commonly linked to schizophrenia.
Other evidence suggests that differences in temporal lobe function are common in people diagnosed with schizophrenia.
The paper is published in the May edition of Cortex, but a pre-print is available at the link below if you don’t have access to the journal.
pdf of full-text paper.
Disclaimer: This study is from my own research group
Neurophilosopher has a great article on a brain scanning study showing that people with synaesthesia have different patterns of brain connections compared to non-synaesthetes.
You read a lot of articles on the brain that use phrases like “wired differently”, suggesting that the connections in the brain are altered.
As the connections in our brain are changing all the time at the dendrite level, often this is just a meaningless way of saying “there’s a difference”.
Perhaps these sort of phrases are best applied to white matter which is the nearest you’ll find to genuine wires in the brain.
White matter fibres run in bundles, they carry electrical signals, and they are insulated by a fatty covering called myelin.
The connections of white matter have been quite hard to study in living people until the development of diffusion tensor imaging (DTI), a brain scanning technology that can specifically pick out the white matter fibres and create maps like the one in the picture.
Rarely when articles talk about “different brain wiring” do they actually mean detectable differences in white matter though.
In the DTI study covered by Neurophilosopher this is exactly what was studied, and it does indeed seem to be different in people who experience synaesthesia, a condition where some of the senses are crossed so, for example, numbers might be also experienced as colours.
DTI is a type of magnetic resonance imaging (fMRI) that measures the diffusion of water molecules. In the brain, water diffuses randomly, but tends to diffuse easier along the axons that are wrapped in myelin, the fatty protein that insulates nerve fibres. Diffusion tensor imaging can therefore be used to infer the size and direction of the bundles (or “fascicles”) of white matter tracts that connect different regions of the brain (above).
The Dutch researchers show that synaesthetes have more connections between the two adjacent areas in the fusiform gyrus than non-synaesthetes. They report their findings in the June issue of Nature Neuroscience.
As well as showing these differences between synaesthetes and non-synaesthetes, the authors also show that there are also differences in connectivity between synaesthetes who differ in the intensity of their sense-mixing experiences.
In other words, the researchers found people with synaesthesia had white matter ‘wiring’ between sensory areas that others don’t have, and that this wiring differed depending on how much synaesthesia the participants experience.
Just from the fantastically straight-forward explanation of DTI imaging given above, you can see that it’s a wonderfully written article.
Have a look at the full piece for more on this fascinating study.
Link to Neurophilospher on ‘Imaging of connectivity in the synaesthetic brain’.
Link to abstract of scientific study.
The New York Times has a review of a new book on how people have overcome brain damage through neuroplasticity – the brain’s ability to re-organise itself.
While this is nothing new, the brain has always had this ability, the discovery is relatively recent and rehabilitation is increasingly designed to take advantage of this process.
The book is called The Brain That Changes Itself and is apparently a series of case studies of how people’s lives have been improved by technology, psychotherapy or behavioural changes.
I suspect much of the excitement about neuroplasticity has been generated by the popularity of ‘cognitive fitness’ games, books and video games, all of which are based on the idea that you can ‘train your brain’ like a muscle.
While there is some truth in this, the effects are much less than many people might expect and certainly, most people don’t completely recover from brain injury.
I wonder if this book, like Peter Kramer’s 1994 book Listening to Prozac (ISBN 0140266712), will showcase the success stories, while most people’s experience will be much more modest.
There’s certainly nothing wrong with presenting the highlights of new and exciting therapies, but I wonder whether it raises some people’s expectations unrealistically.
Anyway, I’ve not read the book yet so I will have to see how it is tackled when I get a copy, and we’re certainly crying out for an accessible treatment of the subject.
Brain Damage, Brain Repair (ISBN 0198523378) is a great academic text, but it’s hardly something you’d take to the beach with you.
Link to NYT review.
Link The Brain That Changes Itself book / author’s website.
San Francisco’s interactive science museum Exploratorium has a fantastic online memory exhibit, that includes articles, games, demonstrations and lectures from leading memory researchers.
The exhibit looks at the science of memory, as well as how it is used in art.
There’s a great article that explains memory distortions via Philip K. Dick and a try-it-yourself demonstration.
And for some unknown reason there’s a slideshow of a sheep brain dissection, when what would be genuinely informative would be to see the memory structures in the human brain.
It’s like going to an air show and watching someone take a bicycle apart.
Apart from that, the site’s fantastic. The lectures are particularly good. Most cover the science of memory, but one is on ideas of forgetting in myth and story.
Link to Exploratorium memory exhibit.
A study that followed the lives of young males for 20 years has found that cognitive ability predicted whether the person was likely to engage in violence or theft if they had a tendency for antisocial behaviour.
Way back in ’79, the researchers recruited 698 males from 12 to 18 years of age from a random telephone survey in New Jersey. They kept in contact with them until the year 2000.
The researchers interviewed the participants and asked about any antisocial behaviour or offences.
They also tested the participants using neuropsychological tests of verbal IQ and executive function – the ability to co-ordinate mental resources that is closely linked to the frontal lobes.
In the males who did end up engaging in antisocial behaviour, the ones with cognitive difficulties tended to be violent, while the ones who were cognitively more able tended to steal.
In other words, low mental ability was associated with violence while the brighter individuals tended to engage in theft.
This could be because successful theft could require more thought, from planning a robbery to tricking another individual, whereas successful violence just requires a target.
One of the difficulties in interpreting these sorts of studies, is that they rely on participants admitting their own offences, so maybe more intelligent people are likely to describe their crimes differently.
However, it certainly wasn’t the case that more able people simply kept quiet about antisocial behaviour, as both reported wrongdoings, but of a different type.
UPDATE: Romeo Vitelli makes an interesting point in the comments:
All things being equal, theft is regarded as being less serious than violence is. Given that this study depends on self-report, are the ones who commit violence less likely to admit to committing violent crimes than the ones who commit theft?
Link to abstract of scientific paper.
Link to brief jargon-free summary.
The Washington Post has a fascinating article on the psychology of mental accounting – a seemingly simple process but one which seems to have curious effects on how we decide to spend our money.
The article suggests we mentally divide our money for different purposes, and tend to be reluctant to change our thinking, even when it is against our interests.
There’s a nice example of turning up to the cinema and discovering you’ve lost your $20 ticket. How would you feel about shelling out for another one?
Compare this situation to one in which you turn up to the cinema to buy a ticket, but find you’ve lost a $20 bill. How would you feel about buying a cinema ticket in this situation?
Intuitively, it seems as if the first situation is worse, because you’re buying another ticket, when, in fact, the loss is exactly the same in both situations.
It also seems that we assign different sources of money to different purposes, despite the fact that money is completely interchangeable:
Arkes and his colleagues once cited an anecdote in a study: Employees of a publishing firm who were in the Bahamas for an annual meeting were each given a cash bonus for getting a big contract. Almost to a person, the bonus recipients took the money to a local casino and blew it. What is interesting is that most of these people did not lose more than the $50 — they slowed down or stopped when they felt they were playing with their “own” money rather than with the $50 of “free” money. The irony, of course, is that the $50 these people lost was their own money, too.
The article has got some more great examples of how we make spending decisions based on our own idosyncratic internal accounting schemes.
UPDATE: An interesting note from jswolf19, grabbed from the comments:
In my mind, the loss of the ticket and the loss of $20 are not the same. It’s possible that I might find either the ticket or the $20 later (that it’s misplaced instead of lost). However, the ticket will have become useless to me whereas the $20 will not have.
Link to Washington Post article ‘mental accounting’ (thanks Enchilada!)
Wired and The New York Times have just each published an article about the use of virtual reality to simulate the experiences of schizophrenic psychosis. This is a PR success for its creator, Janssen-Cilag Pharmaceuticals, but its hardly news, as they’ve been showing the system since 2000.
The system originally had the appalling name ‘Paved With Fear’ and was unveiled in September 2000.
The company, who manufacture the antipsychotic drug risperidone (aka Risperdal), toured the world with the ‘Paved with Fear’ truck.
The rig allows users to put on the VR goggles and explore a virtual world, while the software is programmed to simulate hallucination-like experiences – abusive voices, visual scenes transforming into sinister images and so on.
It was covered in 2002 by an NPR radio show that has some audio and images from the simulation.
In one simulation, a schizophrenic has auditory and visual hallucinations while trying to refill a prescription, and sees the word “poison” on a bottle of pills.
Its not often you meet psychotic patients who hallucinate drug company PR, but Janssen seem to think that refusing their product is a sign of madness.
The system has been taken around the world and show to police, psychiatrists and families of people with mental illness.
The system has since been re-branded with the less stigmatising name ‘Virtual Hallucinations’ and continues to make the headlines, despite the fact that many other people have used VR to simulate psychosis.
I wrote an article in 2004 about some of the systems and talked to their creators, and got some feedback from a programmer and a psychologist who have experienced psychosis themselves.
They concluded that while VR simulations might be a useful simulation of the perceptual disturbance in psychosis, it also involves distortions of meaning and thinking that can’t be captured.
The systems covered in the article were based on experiences taken from patient interviews and were made independently.
Psychiatrist Dr Peter Yellowless recently published a paper on the system he developed, and one system has been built in online virtual word Second Life. There are instructions online so you can try it yourself.
Link to NYT article ‘A Virtual Reality That’s Best Escaped’.
Link to 2004 article on using VR for psychosis simulation and research.
Link to summary of Yellowlees’ paper on psychosis simulation.
Link to instructions for Second Life simulation.
Mind Hacks 