A brief history of aspirin

Wired has a brief article on the history of aspirin, which contains the surprising fact that the same pharmacist who first synthesised the popular headache pill also first synthesised heroin.

1899: Felix Hoffmann, a young pharmacist working for the German pharmaceutical company Bayer, patents a new pain reliever. The trademark name is aspirin.

Hoffmann, who was said to be seeking an effective pain reliever for his father’s rheumatism, successfully synthesized acetylsalicylic acid in August 1897. It would later be marketed as aspirin ‚Äî “a” for “acetyl” and “spirin” for Spirea, the genus name of the source plant for salicylic acid, the pain-relieving agent.

That August, incidentally, was an especially fertile period for Hoffmann: The month also saw him synthesize heroin, which he accomplished accidentally while attempting to acetylate morphine to produce codeine. Obviously, that discovery didn’t pan out like aspirin.

It turns out that aspirin was a huge money-spinner for pharmaceutical company Bayer owing to persuasive marketing and powerful patent lawyers.

Link to Wired on the birth of aspirin.

The best of psychology and neuroscience on Twitter

Many thanks for sending or posting all your suggestions for psychology and neuroscience Twitter feeds to follow. After watching the streams for a few days, here are my suggestions for some of the best:

@mocost
Probably the single best mind and brain Twitter feed I’ve yet found. By the author of the excellent Neurophilosophy blog. Diverse, regularly updated, fascinating.

@noahwilliamgray
One of the neuroscience editors for Nature, who used to write for the underperforming ‘Action Potential’ blog. However, he’s really hit his stride since moving on to better things and he posts a load of interesting material to his feed, including live updates from a recent conference. Has a slight neurobiological tendency.

@PsychScience
The Association for Psychological Science’s Twitter feed focuses on new discoveries and association members in the news. The ‘members in the news’ posts usually lead to good articles but you’ll need to follow the link to find out what they’re about as it often doesn’t say.

@allinthemind
Wonderful radio show that keeps going from strength to strength and now posts to Twitter. Previews of upcoming programmes and commentary from the programme’s switched on host Natasha Mitchell.

@anibalmastobiza
A Spanish cognitive scientist who blogs in Spanish but Tweets in English. A high signal to noise ratio and with only 15 followers at the moment, one of Twitter’s best kept secrets.

@DrShock
A Dutch psychiatrist who you may know from the blog of the same name. Links to interesting mind, brain and mental health snippets with the occasional bonus tweet in Dutch about, well… I’ve no idea.

@RightThought
A psychotherapist who often posts useful and interesting links to mind and brain news, as well as the occasional productivity and successful living tip.

@sandygautam
Like being rained on with psychology and neuroscience content. A high volume, stream of consciousness feed, but luckily a stream with plenty of gold nuggets in it.

@mentalhealthuk
I have no idea who or what mentalhealthuk are, but they refeed pretty much every mention of mental health in the media to their Twitter account. High volume, but very complete.

I’m sure there are others that I’ve not discovered or who have been quiet since I’ve been watching, so I’ll post here when I find further gems.

Please note that the Mind Hacks feed @mindhacksblog just alerts you to new blog posts, but, after some weeks of trying to work out what the hell I’d do with it, I have started posting to Twitter myself.

You can find me at @vaughanbell, where I’ve essentially been posting mind and brain stuff I find interesting or curious. Not a great surprise I know, but hopefully it’ll be of interest.

Brain stimulation – the next interrogation aid?

Photo by Flickr user Magh. Click for sourceAn article just published online for the Behavioural Science and Law journal discusses whether magnetic brain stimulation could be used in lie detection and interrogation.

It is based on the premise that as cognitive neuroscience works out the brain circuits for lying, a technique called transcranial magnetic stimulation (TMS) could be used during an interview to disrupt the function of these pathways.

The article specifically pitches this idea as a possible ‘lie detection’ method, as so far, research conducted by the authors suggest that disrupting parietal cortex function, on average, slows the response time for lies and but doesn’t affect response time for truthful responses – albeit in a very controlled laboratory experiment.

In other words, the idea is that TMS could be used to help distinguish truthful responses from untruthful ones.

My first thought on reading this was that someone is bound to be thinking of this technique as a way of inhibiting the relevant circuits to prevent lying, or at least increase the likelihood of truthful responses.

It’s probably true to say that deception research is in its very early days and its not even clear whether such things as distinct ‘deception circuits’ even exist.

However, from what we know from now-public secret military research in this area, it’s clear that many of these sorts of techniques are simply tested empirically.

Essentially, whether there is a good theoretical basis or not, national security agencies are much more likely simply to try the techniques and see what the outcome is.

The Behavioural Science and Law article sticks firmly to the possible civilian uses for this technology, discussing the legal and ethical issues within a domestic law framework, but you can bet that the spooks are already thinking ahead on this one.

Link to ‘Non-invasive brain stimulation in the detection of deception’.
Link to PubMed entry for same.

Psychological characteristics of vicious dog owners

An article on the psychological characteristic of vicious dog owners has just appeared online in the compelling academic publication, The Journal of Forensic Sciences, finding that those who who own dangerous dogs are more likely to endorse antisocial and psychopathic character traits and more likely to report criminal behaviour.

The study was led by psychologist Laurie Ragatz who collected data from 869 college students who completed an anonymous online questionnaire assessing type of dog owned, criminal behaviors, attitudes towards animal abuse, psychopathy, and personality.

It’s only a correlational study but the introduction has a nice summary of the research findings as well as a previous study on the same topic:

Each year, 4.7 million people are bitten by dogs, of which 386,000 are seriously injured and over 200 die. Several dog breeds have been labeled “vicious” or of “high-risk” for aggression. To date, only one empirical study has examined the characteristics of persons who choose to own their high-risk dogs. Barnes et al. reports that owners of Akitas, Chow-Chows, Dobermans, Pit Bulls, Rottweilers, and Wolf-mixes endorsed approximately 10 times more criminal convictions than owners of nonvicious dogs. Further, vicious dog owners reported more crimes involving aggression, children, alcohol, and domestic violence than owners of nonvicious dogs.

The current research sought to replicate and extend these findings with a college sample. The present study compared nondog owners and owners of vicious, large, and small dogs on engagement in criminal behavior, general personality traits (i.e., impulsive sensation seeking, neuroticism-anxiety, aggression-hostility, activity, and sociability), psychopathy, and attitude towards animal maltreatment.

…As hypothesized, a significant difference in criminal behavior was found based on dog ownership type. Owners of vicious dogs were significantly more likely to admit to violent criminal behavior, compared to large dog owners, small dog owners, and controls. The vicious dog owner sample also engaged in more types (i.e., violent, property, drug, and status) of criminal behavior compared to all other participant groups.

Personality traits were examined and vicious dog owners were significantly higher than controls on impulsive sensation seeking. Examining psychopathic traits, owners of high-risk dogs endorsed significantly more characteristics of primary psychopathy (e.g., carelessness, selfishness, and manipulative tendencies) than small dog owners.

Comparing owners of vicious dogs to other groups, no significant differences were found regarding secondary psychopathy (e.g., impulsiveness or self-defeating behaviors) or attitudes towards animal maltreatment.

Among the college sample, the vicious dogs were predominantly male and weighed 68 pounds. The owners had more self-reported overall criminal behaviors as well as violent criminal behavior. They endorsed significantly more sensation seeking and primary psychopathic traits.

Link to article.
Link to DOI entry for same.

“My story is about not giving up hope”

We’ve reported before on brain imaging research that shows brain activity in those in a ‘persistent vegetative state’. What I didn’t know until today was that one subject in this research, Kate, has since woken up. This YouTube video tells Kate’s story:

Kate suffered from what was probably brain stem encephalitis at the age of 23. She was the first patient to be scanned by <a href="http://www.mrc-cbu.cam.ac.uk/people/adrian.owen/
“>Adrian Owen as part of his research into the mental lives of those in persistent vegetative states. Findings from this research support what Kate herself is able to say in the video: we need to be very careful before making life and death decisions on behalf of people who appear unresponsive.

2009-03-06 Spike activity

Quick links from the past week in mind and brain news:

The Economist discusses whether the famous Dunbar number, the maximum limit of human relationships, holds on Facebook.

A person who experienced the identity loss memory disorder dissociative fugue is interviewed in The New York Times.

BBC News reports that Malaysia is attempting to curb its suicide rate by planning to arrest those who attempt suicide.

Philosopher Eric Schwitzgebel asks what is an illusion, exactly?

Neuronarrative reports on a new study finding people tend to view leaders more favourably once they’ve died!

Drug giant and makers of Seroquel (quetiapine) lied about their data showing that the antipsychotic drug isn’t as effective as its competitors, reports the Clinical Psychology and Psychiatry blog.

The New York Times reports on research showing that interrupting an experience, whether dreary or pleasant, can make it significantly more intense.

The US Army’s group of ‘weaponised anthropologists’, the Human Terrain System, get slammed by a Marine Corps major in a military publication. Wired has the story.

The Onion, on news that a Lovecraftian school board member wants madness added to the curriculum. C’thulhu fhtagn!

Science News reports on a new study that links the genetics of Autism and bellyaches.

A long and confusing article on why minds are not like computers is published in The New Atlantis. Would greatly benefit from the insights from philosophy of mind.

Nature has an excellent article on the sociology of science and why we need a third way after the extremes of hard scientific realism and social constructionism. By the always interesting Harry Collins.

Gender effects in <a href="http://sciencenews.org/view/generic/id/41304/title/Playing_for_real_in_a_virtual__world
“>children’s play are seen in virtual worlds, reports Science News.

Furious Seasons reports on a recent study looking at the (large) placebo effect in studies of antidepressant treatment for adolescent depression.

Is patriotism a subconscious way for humans to avoid disease? asks the always engaging Carl Zimmer in Discover Magazine.

The Guardian reports on research suggesting that some people who suffer stroke develop PTSD after their experience.

Texting is associated with superior reading skills in children, reports the BPS Research Digest.

The New York Times has an interesting article looking at the psychology of rewarding students for study or good performance in light of mixed evidence of how effective the practice is.

ABC Radio National’s Ockham’s Razor has programme on how errors of grammar, punctuation and inaccurate scientific terminology can complicate important social issues.

Dr Shock covers some interesting research on the pros and cons on using PowerPoint presentations in teaching for learning by students.

Also from Dr Shock an awesome video showing how some stunning 3D illusion street art was created.

The New York Times reports that skin cells from people with Parkinson’s disease have been converted in a test tube to dopamine neurons.

Encephalon 65 faces the facts

The 65th edition of the Encephalon psychology and neuroscience carnival has just appeared online, this time hosted at Podcat Black and illustrated with some emerging unbidden from the world.

A couple of favourites include a fantastic post on the Edwin Smith Surgical Papyrus which outlines some Ancient Egyptian brain surgery and a series of posts introducing the principles of evolutionary neuroscience through the Cthulhu mythos.

There’s many more engaging articles and the pareidolia face images are great fun as always.

Link to Encephalon 65 on Podcat Black.

The cognitive neuroscience of eye contact

Image by Flickr user feastoffools. Click for sourceThe latest Trends in Cognitive Sciences has a fantastic review article on the cognitive neuroscience of eye contact, demonstrating how this fleeting social connection has a powerful impact on the mind and brain.

Past research has shown that making eye contact has an impact on social perception and subsequent behaviour.

The article notes that eye contact has been found to increase the likelihood of recognising someone and helps work out whether someone is male or female.

It also seems to increase general arousal and fixes attention – we’re less likely to notice things happening on the periphery of our vision if we’re staring at a face with eye contact than at a face where the eyes are diverted to the side.

In neuroimaging studies eye contact has been found to increase activity in a group of areas (medial prefrontal cortex, superior temporal gyrus, fusiform gyrus) that have often been associated with social interaction across a wide range of studies.

Interestingly, the authors suggest that basic eye contact information might be detected by a specific subcortical mechanism that quickly detects simple light/dark differences, presumably to pick out the direction of the pupil, which then triggers more complex social processing to make sense of its social meaning.

It’s an interesting field, not least because recognising eye contact and following the gaze direction of others are thought to be some of the most fundamental building blocks on which social communication develops in babies.

Children with autism have been found to show radically different patterns of eye contact recognition and gaze direction, and the authors suggest that one cause could be a problem with the these eye contact neural circuits which leads to slow or impaired social understanding.

Link to article on eye contact.
Link to DOI entry for same.

The cognitive fallacy of East is East and West is West

New Scientist has an excellent article on East-West psychological differences and why they may be more to do with local lifestyle than broad cultural generalisations.

Experiments that compare the responses of, for example, Americans and East Asians, are often used to support theories that Westerners have an analytical, individualistic world-view, while Easterners have a holistic, collectivist outlook.

This has been reported in studies that have compared how Westerners and Easterners categorise objects (shared features vs functional relationships), reasoning about causes for people’s behaviour (individual state of mind vs social situation) and, most famously in recent years, how people view visual scenes (focus on objects vs focus on background).

However, the NewSci article discusses a number of studies suggesting that these differences may not be to be with broad cultural definitions but to do with the lifestyle of the local population. In fact, these exact same differences can be found within both Eastern and Western cultures.

So it’s not all that surprising, perhaps, that other studies find that local and current social factors rather than the broad sweeps of history or geography tend to shape the way a particular society thinks. For example, Nisbett’s group recently compared three communities living in Turkey’s Black Sea region who share the same language, ethnicity and geography but have different social lives: farmers and fishers live in fixed communities and their trades require extensive cooperation, while herders are more mobile and independent.

He found that the farmers and fishers were more holistic in their psychology than herders, being more likely to group objects based on their relationships rather than their categories: they preferred to link gloves with hands rather than with scarves, for instance (Proceedings of the National Academy of Sciences, vol 105, p 8552). A similar mosaic pattern of thought can be found in the east. “Hokkaido is seen as the Wild West of Japan,” says Nisbett. “The citizens are regarded as cowboys – highly independent and individualistic – and sure enough, they’re more analytic in their cognitive style than mainland Japanese.”

Even more surprisingly, the article describes how these same cognitive tendencies are malleable – they can be changed in individuals by simply priming them with individualistic or collectivist concepts.

The article is a thought-provoking challenge to the East – West psychological stereotypes common in both the popular press and the scientific literature and discusses some intriguing studies I was completely unaware of.

By the way, the author is Ed Yong, who writes the Not Exactly Rocket Science blog we often link to.

An excellent article that is highly recommended.

Link to ‘Beyond east and west: How the brain unites us all’.

Finding a Twitter flock

I’m interesting in creating a list of people on Twitter that Mind Hacks readers might be interested in: psychologists, neuroscientists, psychiatrists, AI hackers, anthropologists, sociologists, science writers, philosophers – you know the sort.

However, it seems quite hard to track down people by their interests.

So if you follow, or are, someone who posts lots of interesting mind and brain stuff on Twitter, leave a comment on this post, or email me using this web form with Twitter in the title.

My only caveat is I’m not particularly interested in, for example, a psychologist who mostly twitters about their cat, the news, sport or whatever. They need to be a good source of mind and brain insights.

I’ll filter the list and post it up here.

GABA gimmick in a can

Jones GABA a slickly advertised new energy drink that contains the neurotransmitter GABA, described as enhancing “focus + clarity” and putting you “in the zone”. It is backed by ‘one of the world’s leading authorities on natural medicine’ Dr Michael Murray, who seems completely unaware that GABA doesn’t cross the blood-brain barrier and so drinking it is unlikely to have any effect.

The active ingredient in the drink is called ‘Pharma GABA’, which, despite the ‘Pharma’ prefix is just powdered GABA, commercially sold, normally as a ‘nutritional supplement’.

This has actually been subject to research, albeit in a poorly controlled trial of 13 people in one experiment, and two groups of four people in another. It used surrogate outcomes (measuring saliva and EEG) rather than actually measuring stress or focus and was completed by the company that sells the product.

But even without this experimmercial, we can be pretty sure that swallowing GABA doesn’t work, because, despite various experiments that have investigated the neurotransmitter, it has never been found to cross the blood-brain barrier in any significant way.

However, this isn’t the first junk food product to include neurotransmitters as a gimmick. We found some Japanese GABA sweets for sale last year.

I have to say, I love the geekiness of having neurotransmitter junk food, but it would be infinitely better if it wasn’t packaged with junk science.

It would also be infinitely better if it was highly caffeinated, but that’s just a personal opinion.

Link to GABA in a can spoilt by the pseudoscience (thanks Sara!)

Psychology and advertising

Here are links to some old posts about psychology and advertising. About three years ago I was writing a lot about this, and I just thought I’d collect them here:

Longer posts:

Is there a science of advertising?
Decoding adverisements
Cognitive psychology & advertising
Music wine and will
advertising influences familiarity induces preference
neuroscience and advertising
where do implicit associations come from?
Book review: Influence (by Robert Cialdini)
Does advertising erode free will?

‘Briefly noted’ and links

the price is right regardless of the cost
When choice is demotivating
Experimental psychology of advertising resources
Why can’t we choose what makes us happy
The Endowment effect and marketing
A quick and miscellaneous list of advertising links

Update: Book review of Ad Nausam, Sir Humphrey teaches questionnaire design

Uncannily beautiful

Below are a couple of strangely beautiful delusions described in a 1993 paper on ‘The reliability of three definitions of bizarre delusions’ published in the American Journal of Psychiatry:

A 22-year-old woman had the delusion that thoughts and feelings emanating from her mother’s unconscious were being carried in raindrops that fell on her air conditioner. When the raindrops hit the air conditioner they made a noise, and simultaneously these thoughts and feelings merged with her own unconscious. This merging had resulted in her own mental illness.

A 27-year-old man had the delusion that the voice he heard throughout the day was that of an invisible girlfriend. His girlfriend gave him advice and told him to do things. At night she would come to him, although still invisible, and they would make love.

Link to PubMed entry for paper.

Rewiring the brain for fun and profit

Wired has just published an excellent two part article on neuroengineering, the practice of altering the brain with electronics or optics.

It looks at a number of interesting projects, from light controlled neurons to magnetic brain stimulation, and focuses on the work of talented neuroengineer Ed Boyden who I had the pleasure of doing a joint talk with at a SciFoo conference.

In fact, TMS gets electricity into the brain peacefully, without either cutting it open or shocking it with millions of volts.

The target area of the brain is treated like the coil in a generator, subjected to rapidly changing magnetic fields until electricity begins to dance across its neurons. Unlike the optical switch developed by Boyden and Stanford’s Dr. Karl Deisseroth, TMS doesn’t reach the deeper regions of the brain, but there are a lot of important and interesting areas in the cortex where TMS delivers its current. It’s also far less precise than the optical switch, although TMS seems positively surgical when compared to the imprecisions of the pharmaceuticals we pump into our bodies.

The second part is probably the highlight, discussing the possibilities of having these technologies more widely available so your average garage hacker can tinker with them (and themselves), and what ethical dilemmas this might cause.

Link to ‘Inside the New Science of Neuroengineering’.
Link to ‘How Neuroengineering May Change Your Brain.

Memory loss at the movies

Neurophilosophy has a great post about how amnesia is represented in cinema, concluding that there’s only three movies that accurately represent memory loss.

The post is based on an article from the British Medical Journal by clinical neuropsychologist Sallie Baxendale who has written a number of excellent articles on topics such as epilepsy in music, at movies, and in the saints.

The three films mentioned as accurate depictions of amnesia are the masterpiece Memento, Spanish language film Sé Quién Eres, and, surprisingly, the Disney animated feature Finding Nemo.

The Neurophilosophy article is also illustrated with video clips so you can see some of the films under discussion.

Link to Neurophilosophy on ‘Amnesia at the movies’.