2006-07-28 Spike activity

Quick links from the past week in mind and brain news:

spike.jpg

Research in PLoS Biology reports that functional connections in the brain transform experience into memory.

Some researchers still not disclosing their conflict of interest in key studies, reports AADT Blog.

BBC Radio 4 programme Leading Edge discusses body clock genes and mind reading machines.

Metapsychology has an in-depth review of Nancy Andreasan’s book on the neuroscience of genius (via 3Q).

New autism study shows differences in brain structure.

Seed Magazine reports that brain scanning research that suggests that we can process social outsiders as less than human.

Researchers identify what are possibly the first neurons in the development of the human cortex.

Nature Reviews Neuroscience has an in-depth article on molecular and genetic approaches to brain asymmetry and handedness.

The Psychiatric Times explores the link between conduct problems in adolescence and personality disorders in adulthood.

Nature vs nurture via neuroscience

brain_environment_interaction.jpg

For those of who you particularly enjoyed the Prospect article on the interaction between environment and genetics in promoting certain mental states and behaviours, Nature Reviews Neuroscience has an in-depth review article on how neuroscience is helping understand this complex process.

If you haven’t got time to get down and dirty with a full-on review article though, Brain Ethics has a fantastic summary that captures the main points.

Link to full text of Nature Reviews Neuroscience article.
Link to Brain Ethics article.

Reflected glory

new_hair_mirror.jpgThere have been some critical commentaries recently that suggest that the hype over mirror neurons has become unbearable and a backlash is about to begin.

Mirror neurons are cells in the brain that are active both when a person is performing an action, or when they see someone else perform an action, and have been hypothesised to be involved in perceiving and comprehending others’ actions.

Worryingly, this system has been proposed as the basis of everything from empathy to appreciation of art, with very little supporting evidence.

Both Mixing Memory and Neurotopia have sceptical commentaries on mirror neurons and doubt whether they have been consistently demonstrated in humans in anything other than correlational brain scanning experiments.

This is probably a little unfair, as evidence for ‘mirror neurons’ in humans has been found using subdural (brain surface) electrodes, transcranial magnetic stimulation, fMRI, magnetoencephalography, EEG and when studying patients with action production and recognition problems after brain injury.

That’s quite a lot of converging evidence for the existence of an equivalent human system.

What is a little misleading is that the original studies measured the responses of single neurons in monkeys, whereby the human studies have all been using techniques that measured activation from a group of neurons.

This, and the fact that the recognition and generation of actions also relies on other brain areas, has led some to use the more accurate term ‘mirror system’ in preference to ‘mirror neuron’.

What most of the recent articles seem to be criticising, however, is that the concept is being used as a convenient ‘just so’ story for explaining almost any sort of complex human behaviour, usually by people with a fairly poor grasp of the existing evidence.

It’s easy to see why the idea is attractive. A system that is both involved in producing our own movements and becomes active when we see others moving leads some to infer (perhaps falsely) that we encode others’ behaviour into our brains in quite a direct way.

Even worse, in some retellings of the story, behaviour can include almost anything you care to think of.

As noted by Frontal Cortex, this concept, although flawed, is easy to grasp and user-friendly, making almost anyone an instant ‘expert’ on how the brain supports human interaction.

The reality will probably turn out to have too many qualifications to allow the media obsession with mirror neurons to continue forever, but in the mean time, don’t get put off by the hype.

The findings are fascinating and the mirror system will surely play an important role in our future understanding of human neuropsychology, even if this won’t exactly match how the media portrays it the moment.

Link to Mixing Memory article.
Link to Neurotopia article.

The intelligent environment

school_student.jpgContinuing our IQ theme, the New York Times has a fascinating article on the contributions of genetics and environment to IQ and argues that the effect of the environment becomes much more crucial for those from low-income backgrounds.

[Psychologist Eric Turkheimer] has a reputation as a methodologist’s methodologist. In combing through the research, he noticed that the twins being studied had middle-class backgrounds. The explanation was simple – poor people don’t volunteer for research projects – but he wondered whether this omission mattered.

Together with several colleagues, Turkheimer searched for data on twins from a wider range of families. He found what he needed in a sample from the 1970’s of more than 50,000 American infants, many from poor families, who had taken I.Q. tests at age 7. In a widely-discussed 2003 article [pdf], he found that, as anticipated, virtually all the variation in I.Q. scores for twins in the sample with wealthy parents can be attributed to genetics. The big surprise is among the poorest families. Contrary to what you might expect, for those children, the I.Q.’s of identical twins vary just as much as the I.Q.’s of fraternal twins. The impact of growing up impoverished overwhelms these children’s genetic capacities. In other words, home life is the critical factor for youngsters at the bottom of the economic barrel. “If you have a chaotic environment, kids’ genetic potential doesn’t have a chance to be expressed,” Turkheimer explains. “Well-off families can provide the mental stimulation needed for genes to build the brain circuitry for intelligence.”

This interaction between economic background and mental functioning has now been replicated in a number of studies looking at everything from mental illness to criminal behaviour (e.g. see Christian’s previous post).

It seems that the simple summing of genetic and environmental effects is no longer a valid way of understanding how we develop, as the duration, quality and frequency of different life experiences seem to have unique influences on the expression of our inherited traits.

Link to New York Times article ‘After the Bell Curve.
pdf of Turkheimer’s paper.

Born to be bad?

criminal personality.jpgThe latest issue of Prospect magazine features a fresh in-depth analysis of whether there is such a thing as a criminal personality. The author David Rose of the Observer notes that contemporary politicans have tended to focus on the social causes of criminality – think of Blair’s ‘tough on the causes of crime’ speech. But he points to new research showing that genetic factors are also key, in particular he highlights research by Terrie Moffitt and colleagues at the Institute of Psychiatry, including a study showing that whether childhood maltreatment leads to later increased risk of criminality depends in part on the variant of the MAOA gene that a person has. The gene codes for the enzyme monoamine oxidase A, and is involved in the regulation of neurotransmitter levels. A person with a low activity variant of this gene who is maltreated is far more likely to develop antisocial behaviour.

Link to Prospect article (open access).
Link to the Dunedin Study.

Happiness is an impossible dream

adam_phillips_guardian_pic.jpgPsychoanalyst Adam Phillips is interviewed in The Guardian about the paradox of chasing happiness and the negative effects of emotional idealism.

Phillips argues that trying to eliminate all sources of stress in your life is a pointless exercise and we should become better at tolerating difficult situations if we are to be become fully content.

I tell Phillips that at my workstation books with the word happiness in the title arrive unbidden by the hour. They include: Daniel Gilbert’s Stumbling on Happiness, Richard Schoch’s The Secrets of Happiness, Darrin McMahon’s The Pursuit of Happiness, Richard Layard’s Happiness: Lessons from a New Science and Jonathan Haidt’s The Happiness Hypothesis. Do you read these books? “I’ve looked at them. They seem to me to be the problem rather than the solution.”

Phillips also gives his take on the current focus on CBT as the psychological therapy of choice and the use of psychoanalysis as a long-term therapy for people with socially turbulent modern lives.

Link to article ‘Happiness is always a delusion’.

The Flynn effect is reversing

rubix_cube_solved.jpgAmerican Scientist discusses the trend for changes in how well people score on intelligence tests and notes that the Flynn effect, whereby the population has been scoring increasingly well on intelligence tests over time, seems to be slowing down or reversing in some places.

It is well-known is psychology that performance on cognitive tests changes over time and across populations, which is why the most widely used tests (particularly the Wechsler series) have different versions for different countries, and are re-released every few years with new comparison data.

An IQ score is always relative to the average performance of the rest of the population, so an IQ of 100 always means you score the same as the average of the population on a current test.

As new tests are released, this average may shift, so it is difficult to directly compare IQ results from previous versions of a test.

On old tests, however, it was noticed by Flynn that people were scoring better by about 3 points per decade. The American Scientist article notes that this effect is starting to slow down or reverse in some places though.

Does this mean we’re becoming less intelligent? Probably not. It likely reflects the fact that the skill set of population is changing and that we become practiced at different tasks at different rates as modern life develops.

As an aside, IQ tests considered trustworthy by psychologists rarely go above 160, so anyone quoting a 160+ IQ is likely to be talking nonsense.

Link to article ‘Smart as We Can Get?’.
Link to Wikipedia article on the Flynn effect.

The science and culture of hallucinated voices

hearing_phrenology.jpgThis week’s ABC Radio All in the Mind had an edition on auditory hallucinations that discusses the experience of ‘hearing voices’ as well as the neuroscience that might explain them.

Hallucinatory voices are still largely mysterious to science. Originally they were linked to psychotic mental illness and particularly schizophrenia, but it later became known that only about 30% of people who hear voices ever become psychiatric patients.

Furthermore, for some people who hear voices, they can seem to exist as separate conscious entities with their own personalities. Someone may experience a number of voices each with a distinct age, sex and accent.

Research has suggested some explanations for why voices occur (it is know that the auditory cortex is activated with hallucinated voices are heard, suggesting that they may be internal thoughts experienced as sound) but many of these other issues are still unresolved.

The programme discusses the current state of research, as well as talking to two voice hearers about the experience itself, including campaigner Ron Coleman who has been particularly active within the Hearing Voices Network.

The network has taken an alternative view to the medical model, which assumes that voices are a symptom of mental disturbance, and encourages hearers to understand their voices in whatever way best promotes successful living.

Link to ABC Radio All in the Mind on hearing voices.
Link to Wikipedia article on hearing voices movement.

The Mask of Sanity

hervey_clekeley.jpgThe complete text of the classic book on psychopaths and the psychopathic personality The Mask of Sanity is available online as a pdf file.

The book was written by psychiatrist Hervey Cleckley (pictured on the left) and is one of the classics in the field. It is still highly regarded for its in-depth case studies of psychopaths.

Contrary to most Hollywood depictions psychopaths are not necessarilly people who enjoy causing pain or suffering, but are thought to lack empathy and, therefore, tend to use violence to acheive an end, without concern about the impact of their actions.

There’s further information on psychopaths and psychopathy here for those wanting an introduction.

Link to complete text of The Mask of Sanity (1.4Mb).
Link to webpage on psychopathy.

PsyWar

information_radio_leaflet.jpgPsyWar is a website dedicated to the dark arts of psychological warfare and propoganda.

It has a huge archive of propoganda and psychological warfare material from wars past, including copies of leaflets dropped into enemy territory to persuade soldiers and civilians that they were fighting for a lost cause.

The website also has articles and analyses of the techniques used in times past (including a fasinating article on the use of rumour campaigns) with commentary on their effectiveness and cultural impact.

It is interesting to compare these historical materials, largely created by government departments, with the increasing trend for corporations to provide ‘psyops’ services on a consultancy basis (as previously reported on Mind Hacks).

More recently, PsyWar reports on how psychological warfare is being used in the current campaigns in Afghanistan and Iraq.

Link to PsyWar website.

The genetics of violence

shadow_fist.jpgThere’s a thought-provoking piece over at Brain Ethics about the role of genetics in violence, and particularly the role of a gene that codes for a type of monoamine oxidase enzyme involved in the breakdown of certain neurotransmitters in the brain.

The post reports on recent research led by neuroscientist Andreas Meyer-Lindenberg that found that variants of the MAOA gene predicted amygdala size, and both the response of the amygdala and cingulate cortex.

Both the amygdala and the cingulate cortex have been strongly linked to emotion recognition, and the cingulate cortex to empathy and anticipation.

It may be that differences in these structures may make someone more likely to react violently in certain situations.

The full story is a little more nuanced that this, however, and you’re best visiting Brain Ethics for more comprehensive coverage and analysis.

Link to article ‘MAOA and the risk for impulsivity and violence’.

Autism a target for ‘cereal box diagnosis’

rice_krispies_autism.jpgIn a somewhat bizarre turn of events, Kellogg’s Rice Krispies have agreed to print ‘autism awareness’ messages on the side of their US breakfast cereal packets in partnership with American lobbying group Autism Speaks.

Autism Speaks is a controversial group in some areas, as they claim to speak for people with autism and tend to use emotional messages (compare with the UK’s National Autistic Society) to promote the idea that autism is a “neurological disorder” and “the nation’s fastest-growing serious developmental disorder”.

Although autism is associated with serious learning disabilities in some, many with autism are quite functional and happy to be autistic, and resent the idea that everyone with autism has a ‘neurological disorder’.

Along these lines, a recent edition of NPR radio show All Things Considered looked at the views of people with autism who argue that we should be aiming to accept people with autism, rather than ‘cure’ them.

Furthermore, the idea that cases of autism are on the increase is controversial, largely owing to the fact that the diagnostic criteria for autism spectrum disorders has significantly widened in the last 30 years (as discussed recently on Mind Hacks) and the knowledge of autistic-like traits has become more common.

The cereal packets contain a list of “a few of the possible early signs” of autism and then encourages people to consult their doctor if they have concerns about their child.

Link to info on campaign from Autism Speaks.
Link to critical view from Autism Diva blog.

Scientist creates android double of self

ishiguro_self_android.jpgHiroshi Ishiguro, director of the Intelligent Robotics Lab at Osaka University in Japan, has created an android double of himself and intends to use it to give lectures to test how well his creation recreates the ‘presence’ of genuine human interaction.

Ishiguro was recently in the news when he demonstrated a female android he had created which was a copy of a popular Japanese news reader.

One of his main aims is to understand the subtleties of face-to-face human interaction so he can reproduce this artificially and overcome the so-called ‘uncanny valley‘ that makes close-to-human robots seem synthetic and unnatural.

Link to Wired article on Ishiguro’s android double.

Probe the brain

PBS has a fun flash game where you can recreate Wilder Penfield’s brain stimulation experiments from the safety of your own desktop on a virtual, er, human.

If the anyone actually looked like that, I suspect that having brain surgery to help alleviate epilepsy, or a neuroscientist poking round on the surface of your brain with an electrode, would be the least of your worries.

Link to brain probe game (thanks Annie!).