Undercover psychiatry

An interesting historical snippet from p48 of psychiatrist Giovanni Stanghellini’s book on the phenomenology of psychosis, Disembodied Spirits and Deanimated Bodies:

The German psychiatrist Karl Willmanns, who would later be director of the Heidelberg Clinic until the rise of the Nazis, published a book [in 1906] on the disenfranchised. He had been following them around at night in the outskirts of town, dressed as one of them, often inviting them into his own home, and ‘lending’ them money.

In his book, Zur Psychopathologie de Landstreichers, Willmanns sought to show how many of the homeless were schizophrenic. His university post, then the most important in German psychiatry, was taken from him, apparently because he diagnosed a form of hysterical blindness in Adolf Hitler.

The book itself is concerned with exploring psychosis using the philosophical tradition of phenomenology, which attempts to carefully describe and understand the structure of subjective consciousness.

Needless to say, this is particularly important so scientific studies can aim to understand what it is important to try and measure in conscious experience, not just attempt to study what is easily measurable.

However, not everyone believes that our own subjective experience is necessarilly a reliable guide to even the conscious mind.

Philosopher Eric Schwitzgebel is a particularly strong critic, suggesting that ‘naive introspection’ is inherently flawed. His debate with psychologist Russell Hurlburt, who disagrees, was recently published as a book.

Link to review of Disembodied Spirits and Deanimated Bodies.
Link to details from publisher.

Exporting psychological treatments, importing wisdom

A recent 60 country World Health Organisation study found that depression is the most serious chronic illness, worse than angina, arthritis, asthma, and diabetes. Unfortunately, the majority of people who experience depression live in low income countries where help is least likely to be available.

The New York Times has a fascinating article on an ongoing project in Goa, India, that screens every attendee at a local health centre and then uses psychological therapy to help with low mood or anxiety.

It’s not a simple case of just using Western techniques in a new environment.

As the NYT article mentions, mental illness carries a significant stigma in many cultures. For example, a diagnosis may not only be stigmatising for the affected person, but it may also mean the person’s children are less likely to be thought of as suitable marriage partners, potentially affecting the whole family’s future.

Futhermore, depression is known to present quite differently in some non-Western cultures. Studies have found that people are more likely to report ‘somatic symptoms’ such as diffuse pains or tiredness, rather than low mood or emotional problems.

This is partly due to stigma, but sometimes because certain languages don’t have the same, or even such a varied vocabulary for emotions and mental states.

I’m currently working with a Pakistani psychiatrist who often surprises me by pointing out that even what I assume are relatively straightforward words, such as depression or anxiety, might not have a direct translation in some Asian languages.

All of these issues mean that the treatment centre in Goa tackles the issue in a slightly different way:

Most are also apparently wary of visiting a mental hospital. In India, the stigma of mental illness remains strong. To minimize the problem, health workers avoid using the words “mental illness,” “depression” or “anxiety” with patients, relying on more commonly used words like “strain” and “tension.”

The patients “are happy to talk,” Dr. Sudipto Chatterjee, a psychiatrist at Sangath, said, “as long as you stay away from the idea of mental illness.”

I find the issue of having different vocabularies for our mental states fascinating.

The philosopher Wittgenstein noted how difficult it is to agree on common words for internal states because errors are so hard to correct.

If a mother and child see a rabbit and the child says “elephant!”, the mother can point to the rabbit and correct the misnomer. But what can a mother, or anyone do, if someone ‘misnames’ an emotion?

Or to put it another way, as we don’t have external things to refer to for internal states, how do we ever agree on a vocabulary that is at all meaningful?

I’m always curious when I come across differences concerning emotion words in other languages. For example, Spanish has the same word (verg√ºenza) for shame and embarrassment.

From my native language perspective it strikes me as amazing that another language doesn’t individually label these two states which seem to have such different personal and social implications.

I’m sure there are many reverse examples and many other emotional vocabulary mismatches across the world’s languages.

Link to NYT article ‘Psychotherapy for All: An Experiment’.

The way to a man’s hiccups…

A case of a man with unstoppable hiccups has just been published online in the medical literature. Rather unusually, it turned out they were caused by early stage Parkinson’s disease.

Parkinson’s disease is most commonly associated with movement difficulties and the public most associate it with tremor or shaking.

However, it can have a wide range of other effects (more recently, problems with cognitive functions and mental health have been recognised), although this seems to be the first time hiccups have been reported as an early symptom.

The case study is reported in the journal Parkinsonism and Related Disorders:

The patient was a 62-year-old male who had been suffering from intractable hiccups for more than 6 months. The initial intermittent nature of hiccups became continuous over time. When he was quiet, the hiccups were more prominent, although his symptoms tended to decrease when he was speaking.

The hiccups frequently interrupted his speech particularly towards the end of a sentence. The hiccups tended to disappear when he was asleep. Hiccup frequency increased with emotional stress such as anxiety and anger. The patient was depressed and socially isolated due to the embarrassment caused by his continuous hiccups.

It’s a curious case, but the paper also contains a fascinating paragraph on the causes of hiccups. One cause can be with (unsurprisingly) the organs in the chest, but another can be disruption to part of the brainstem called the medulla.

The causes of hiccup can be divided into ‘peripheral’ and ‘central’. A wide variety of peripheral conditions can cause hiccup including: gastroesophageal pathologies, renal failure, malignancies, medications, abdominal surgery and even myocardial infarction.

Central causes can result from structural or functional disorders of the medulla or various other supraspinal neural elements such as multiple sclerosis, medulla oblongata cavernoma, brainstem tumors, basilar artery aneurysm, cerebellar hemangioblastoma, dorsal and lateral medullary infarctions…

The antidopaminergic agent chlorpromazine is the only drug approved for the treatment of intractable hiccups.

I never knew there was an approved drug for difficult to control hiccups, let alone chlorpromazine, the first antipsychotic drug to be developed and widely used in the 1950s.

However, stranger treatments have been discussed in the medical literature.

Perhaps some of the finest moments in hiccup medicine have come from the small but determined literature on the use of digital rectal massage (translation: finger up the arse) as a treatment.

The abstract of 1990 article from the Journal of Internal Medicine is fantastic simply for its deadpan delivery. Needless to say, it was honoured with an IgNobel award.

Link to PubMed entry for case study.

dothetest.co.uk

bball.jpg
Transport for London have combined two of my favourite things: safety for cyclists and classic Psychology experiments. The website dothetest.co.uk provides a test of awareness that Mind Hacks fans will instantly recognise as an updated (urbanised!) version of Hack #41: “Make Things Invisible Simply by Concentrating (on Something Else)”. Fantastic!

Link to the awareness test here

Link to a previous post on mindhacks.com discussing inattentional blindness

Could you endure such pain, at any hand but hers?

I finally got round to having a look at the New York Times migraine blog and found it full of fantastic writing and some wonderful artwork that aims to capture the perceptual distortions associated with the mother of all headaches.

There’s a particularly good article by Oliver Sacks (his first book was on migraine) who discusses the common geometrical patterns that can occur in the hallucinatory images, known as a form constants.

Interesting, the mathematician Paul Bressloff has suggested [pdf] that these necessarily arise when the firing of neurons in the primary visual cortex is destabilised.

Although Bressloff was particularly addressing certain hallucinations caused by psychedelic drugs, the form constants are, well, constant across conditions, so are likely to arise from a similar process in migraines too.

There are many more articles describing the science, personal stories and art of the head pounding, vision distorting and stomach churning headache. The gallery is particularly good if you’re not familiar with the range of visual effects.

However, no one seems to have touched on a poem by Robert Graves where he uses migraine as a metaphor for love (or is it the other way round?) capturing the beauty and pain of both.

Symptoms of Love

Love is universal migraine,
A bright stain on the vision
Blotting out reason.

Symptoms of true love
Are leanness, jealousy,
Laggard dawns;

Are omens and nightmares –
Listening for a knock,
Waiting for a sign:

For a touch of her fingers
In a darkened room,
For a searching look.

Take courage, lover!
Could you endure such pain
At any hand but hers?

Link to NYT’s Migraine Blog (via Neurophilosophy).

Pimping insomnia

Discover Magazine has an exposé of a recent surge of news stories on insomnia and sleep disorders that stretch from the dull to the frankly unbelievable.

It turns out a fair number seem to be based on press releases from PR firms, some trying to promote hotels, but others coming from the National Sleep Foundation.

The author of the piece looked at the 2005 financial figures from this organisation and discovered that over 80% of its funding came from drug companies and almost three quarters was spent on ‘public education’ – i.e. advertising the existence of sleep disorders.

Of course, sleep disorders can be distressing, disabling and potentially dangerous but research suggests that particularly for insomnia, the judicious use of drugs should be a last resort (most have the potential for addiction), as behavioural and psychological treatments are safer and more effective for most people.

Unfortunately, these approaches are often not available, meaning ‘public awareness’ increases diagnosis but leads to drug prescription, partly because people go to doctors and list what symptoms they think they have from the advertising rather than describing their experiences.

The National Sleep Foundation do a lot of excellent work but the article suggests that there seems to be an element of disease mongering and astroturfing to their promotions.

Link to article ‘Deflating the Bogus Insomnia ‚ÄúEpidemic‚Äù’

Possessed

Film-maker Martin Hampton has created a revealing documentary on four people with different degrees of compulsive hoarding, where individuals incessantly collect household objects, even to the point of not being able to throw out rubbish.

Compulsive hoarding is often linked to obsessive-compulsive disorder, where affected people experience intrusive thoughts or urges to complete certain actions (most commonly ‘washing’ or ‘checking’) even though they know how seriously these intrusions are affecting their lives.

Hampton’s documentary is a remarkably well made account of people with similar urges, in this case to collect and retain, and just lets the individuals and the images speak for themselves (it is also freely available online as wide screen HD, so looks wonderful).

Apparently the documentary was created as part of a Master’s course in visual anthropology, a field I’d not come across before, but which seems to be concerned with documenting the diversity of human experience through film.

Possessed does this admirably and seems to have garnered numerous awards since it’s release.

UPDATE: Grabbed from the comments. An update and a request from the director!

I am the director of this film and am now researching the next stage of the project. I am trying to compile a collection of peoples experiences of OCD and other anxiety based disorders. I have found from experience that although symptoms might be similar, the actual particularities of the obsessions and compulsions are often very varied. For example, one might wash ones hands 30 times a day, but have a very unique self discovered reason for doing so. I would be very grateful to hear of your or any friend / acquaintances experiences / difficulties. Many thanks and I hope you find the film interesting. Please email me at martin@martinhampton.com

Link to Martin Hampton’s documentary Possessed (via MeFi).

Resisting temptation is energy intensive

Cognitive Daily has just published a great write-up and demonstration of a study that illustrates how self-control is an energy intensive process that puts a big drain on the body’s glucose levels.

The article tackles a recent study [pdf] led by psychologist Matthew Gailliot that found that exercising self-control in either conversations or in lab tasks reduces blood glucose levels.

The researchers also found that initial glucose levels can predict how well people do on these tasks and that self-control can be temporarily boosted by giving people a sugary drink.

Cognitive Daily’s have recreated one of the lab tasks. Go and check it out, it’s an excellent demonstration. It makes the task wonderfully clear but also illustrates how even such simple self-control tasks are so difficult.

This sort of ‘self-control’ is heavily linked to attention – in part, the ability to focus yourself on one particular thing and not get drawn into perceptual or emotional distractions.

This study doesn’t tackle brain function, but another recent paper by Gailliot [pdf] does link these findings to what we know about the neuropsychology of ‘self-control’.

This ability is particularly associated with the frontal lobes, which are known to play a key role in inhibiting inappropriate responses.

You can see control break down in interesting ways after frontal lobe damage, which can often lead to a range of impulsive behaviours.

For example, patients with damage to this area might display utilisation behaviour, where they are unable to resist carrying out actions presented by their environment.

The affected person might be unable to walk past a door without trying to open it or sit in front of a coffee cup without sipping it, even when they know it’s too hot to drink.

What’s interesting, is that as the CogDaily article illustrates, we seem to have a mild form of this when we are low on energy or fatigued.

It’s interesting to speculate that the reason we get ‘snappy’ when tired is because we’re less able to control the emotions sparked by small annoyances.

Link to great CogDaily article on self control (try the demo!).

Decorating inner space

The New York Times has a fun article on how psychotherapists decorate their office and what this might portray about the inner life of the shrink.

Psychoanalysts (Freudian psychotherapists) in particular are very careful about what sort of impression they project about themselves, preferring, at least initially, to be as insubstantial as possible so the patient can transfer feelings and impressions onto them, allowing relationship patterns and emotional reactions to be uncovered and worked on.

However, many psychotherapists work from home, using rooms in their house as offices. The NYT piece notes that a recent academic paper in the journal Psychoanalytic Psychology caused a storm by questioning the ethics of this practice, as impressions or even people from the therapists family life might interfere in the crucial relationship forming process.

Of course, the office is also a way of making the patient feel comfortable and at ease and so the tension between how the therapist attempts to express this, and how they express themselves, can be quite revealing.

Freud famously had a painting over his psychoanalytic couch of Jean-Martin Charcot (Freud’s mentor) presiding over the swooning and almost bare breasted young woman ‘Blanche’. No wishful thinking going on there of course.

In the UK, where most psychological treatment happens in the NHS, the rooms are often comfortable but plain outpatient appointment rooms that are shared and booked as necessary.

Occasionally, clinicians will have their own office in which to see patients. In these case, I’ve noticed that psychotherapists and counsellors have a much better sense of interior decoration (all rugs and soft lighting) than clinical psychologists, who tend to go for books and photocopied papers look.

Link to NYT article on therapists’ offices.

2008-03-07 Spike activity

Quick links from the past week in mind and brain news:

Faces in the static. An interesting study looks at brain activation associated with seeing illusory faces in visual noise.

Neuroanthropology discusses recent research looking at the cognitive neuroscience of poverty.

How your name influences your decisions and preferences. The Psychologist has a fascinating article on ‘nominative determinism‘.

The Phineas Gage Fan Club gives a concise summary of the relatively recently discovered ‘grid cells‘.

Industrial psychology may have been invented by mistake. Advances in the History of Psychology tracks down the typo.

Carl Zimmer video interviews neuroscientist Michael Gazzaniga on how discoveries about the brain are challenging our understanding of law.

PsyBlog discusses why psychology is not just common sense.

The Wall Street Journal asks what makes Finnish kids so smart?

Anorexia has the highest mortality rate of any psychiatric disorder and Time magazine investigates the high suicide rate in people diagnosed with the disorder.

Language Log does another fantastic job of debunking dodgy sex difference research.

Pete Mandik is posting entries from his upcoming book ‘Key Terms in Philosophy of Mind’. The first is ‘emergence‘.

Not Quite Rocket Science has one of the most sensible articles you’re likely to read on the recent interesting but over-interpreted ‘brain scan mind reading‘ research.

After the series of recent studies on unpublished drug company data, the UK government intends to bring in a mandatory trials data register. In contrast, the USA seems largely unconcerned.

The Thinking Meat Project has been really good recently. Check it out.

Drunk on water. Frontal Cortex finds a great example of the fantastically powerful influence of suggestion.

Wired has an article on Jill Bolte Taylor, neuroscientist who wrote about her own stroke.

The Neurocritic takes the biscuit, sorry, doughnut, with a write-up of a new study on the neuroscience of eating Krispy Kremes.

Moses on high article available online

Thanks to Debbie from the My Mind on Books blog who managed to track down the original academic article from psychologist Benny Shanon who argues that Moses’ experiences on Mount Sinai may have been due to a hallucinogenic experience.

Shannon suggests that a mixture prepared from the acacia tree and the bush peganum harmala could have been responsible.

The article is freely available so you can read it in detail for yourself. As well as Shanon’s main idea, it also contains a wealth of information about the use of psychedelic plants in the ancient world.

Link to article ‘Biblical Entheogens: a Speculative Hypothesis’.

Delusional psychiatrists

Of Two Minds have found a classic video of a vintage Fry and Laurie sketch where a two people meet in a doctor’s office, both think they’re psychiatrists and the other is delusional.

It’s a funny sketch but it’s also remarkably clever as much of what passes for psychobabble is actually a satire on psychology and psychiatry for those in the know.

Look out for references to Melanie Klein’s (completely wacky) good breast theory, the Bender-Gestalt Test and Lentizol – the trade name for the aged antidepressant drug amitryptyline.

Interestingly, all of these things, and the idea that psychiatrists were mainly interested in psychoanalysis, were most popular in the 1950s and 60s, harking back to a bygone era of psychiatry.

UPDATE: Grabbed from the comments (thanks Jimmy!):

Fry and Laurie did a similar sketch about linguists, riffing on their stereotype (and that of sesquipedalian types in general) as pedants who take their adoration of language to mind-numbing excess. They pepper the conversation with a number of allusions to specific ideas in linguistics.

Run down [and video] at “Tenser, said the Tensor

UPDATE 2: I’ve just discovered another psychiatrist sketch from Fry and Laurie. This one concerns the limits of madness and the practice of putting bread in one’s shoes.

Link to Fry and Laurie psychiatrists’ sketch.

We will please pill

Placebo has its effect through our beliefs and expectations. Because we get many of our assumptions through culture, changing social attitudes could alter how effective it is.

Placebo is sometimes called the ‘expectancy effect’ and describes the fact that our expectations of what the dummy treatment will do can influence the outcome.

We noted before that the colour of the pill can significantly alter its effect, but it’s intriguing to think that we probably get most of these sorts of expectations from our culture.

Bad Science looks at how the strength of the placebo effect has changed over time for different drug trials, suggesting that as our cultural beliefs change, the effectiveness dummy treatments might also change depending on how they’re presented.

Similarly, The New York Times have just published a brief article on a new study that found placebos described as costing $2.50 a dose are more effective pain killers than those presented to participants as costing 10 cents a dose.

In other words, if placebo is a form of faith healing, changes in our collective faith will alter the healing potential of a placebo associated with those ideas.

These social effects on placebo are interesting, because we judge the effectiveness of medications by comparing them to placebo. Furthermore, we know the effectiveness of most medications will be partly explained by the placebo effect.

In other words, changes in our cultural attitudes influence the effectiveness of medication.

While we assume that much of medicine objectively definable, much is only comprehensible by making sense of social issues.

For example, drug side-effects are usually talked about as if they are objectively described properties of the chemical.

However, its easy to see that these actually depend on the person, not the drug.

For example, take the drug terazosin. It lowers blood pressure and shrinks the prostate.

If you have high blood pressure but a normal prostate, the side-effect is a reduced prostate. If you have prostate problems but normal blood pressure, the side-effect is reduced blood pressure. If you have both high blood pressure and prostate problems, it’s potentially side-effect free.

One man’s treatment is another man’s side-effect. This is why the sociology of medicine is as important as biology, chemistry or another other bench-based science in understanding illness and treatment.

Link to Bad Science on placebo.
Link to NYT on price of placebo study.

Moses high on more than Mount Sinai

An Israeli psychologist is asking whether Moses may have been tripping when he saw God on Mount Sinai, suggesting that many of our traditional ideas about the Abrahamic God may have been inspired by hallucinogenic drugs.

Professor Benny Shannon’s apparently cites historical evidence that the religious ceremonies of the Israelites included hallucinogenic plants and further bases his speculation on his own experiences with the reportedly similar psychedelic plant ayahuasca.

Of course, the idea is bound to ruffle a few feathers but as it’s so speculative it’s unlikely to make much of a mark on modern theology.

However, it is not the first nor the wackiest attempt to explain religion as arising from hallucinogenic drugs.

Biblical scholar John Allegro wrote an astounding 1970 book called The Sacred Mushroom and the Cross where he argued that Jesus was actually an hallucinogenic mushroom.

Bear with me on this one.

Allegro suggests that the word ‘Jesus’ was actually a code word for amanita muscaria, the red and white speckled mushroom often featured in fairy tales.

Amanita muscaria, otherwise known as Fly Agaric, genuinely exists and can cause quite intense hallucinations, owing to its effect on GABA receptors in the brain.

According to the theory, a religious sect were using these mushrooms for spiritual purposes, and their visions resulted in the Christian religion.

The Bible contains many words which have since been misinterpreted but with enough (of Allegro’s) linguistic detective work, they can be seen to explain the mushroom cult, rather than the later orthodox Christian interpretation.

To recoin a cliché: you don’t need drugs to enjoy the book, but it helps.

As an aside, the article in Haaretz says Shannon’s theory is published in a philosophy journal called ‘Time and Mind’, but I’m damned (excuse the pun) if I can find it.

Links to the original article gratefully received.

Link to article on Shannon’s theory about Moses.
Link to 1970 Time article on Allegro’s book.
Link to full text of The Sacred Mushroom and the Cross.

5-MeO-DMT in the Pharmaecopia

Heavy metal noiseniks Mudvayne have a song called ‘Pharmaecopia‘ where they list off a load of drugs in a possibly ironic, possibly celebratory way. It’s a bit of a confused list with serotonin and “dopeamine” listed among a rather odd list of street drugs, hallucinogenic plants and commercial pharmaceuticals.

Curiously though, they mention 5-methoxy-N,N-dimethyltryptamine, a drug also known as 5-MeO-DMT that was originally synthesised by legendary psychedelics researcher Alexander Shulgin.

Halcium and morphine,
5-methoxy-n, n-dimethyltryptamine,
Psilocybin, mescaline, aspirin, histomine,
Brushite, darvaset, valium, caffeine, cannabis, and LSD,
Ayahuasca, harmine, give it all to me, I want it

Looking at what’s happened to your hair thus far, it’s probably best not eh?

Presumably, this is the first and only time the full chemical name of a hallucinogenic drug has made it into a song lyric.

Link to audio of song (no, I can’t make out the words either).
Link to lyrics.
Link to Shulgin’s notes on 5-MeO-DMT.