2009 – Page 10 – Mind Hacks

Stairway to loving

There’s a curious case published in the medical journal Epilepsy and Behavior of a young man who had his epilepsy triggered by the sight of stairs. This would cause seizures that would trigger “repetitive hugging and affectionate kissing of one of the people around him”.

Our patient is currently 24 years old. He is a right-handed male with a history of right temporal lobe epilepsy. He had his first seizure when he was 10 years old. His seizures usually started with an aura of a ‚Äúfeeling‚Äù inside his body or abdomen. This feeling, described at times as pain or nausea, lasted a few seconds or a few minutes. His eyes would then widen, he would become confused, and he would look around right and left as if wondering. The seizure would last 1 to 2 minutes with altered consciousness, spitting, and often repetitive hugging and affectionate kissing of one of the people around him.

At times this was followed by head and eye deviation to the left and, sometimes, rotation of the whole body to the left side. Occasionally, he would walk around for a few seconds. These seizures were often precipitated by looking at stairs, whether or not he was walking up the stairs. He learned to avoid looking at stairs to avoid having seizures. He also noted that looking down a flight of stairs did not precipitate his seizures.

I am constantly amazed by both how seizures can be triggered by very specific experiences (such as seeing a certain thing, or hearing a specific sound) and how they can lead to very selective actions.

This is by no means a typical effect of epilepsy but it does raise the interesting question of how these very narrow experiences lead to destabilising brain states which trigger a seizure.

I have heard anecdotal reports from several clinicians that they’ve met patients who can ‘think their way out’ of a seizure by deliberately focusing their thoughts on a specific topic, presumably which reduces the destabilising effect of their original ‘trigger experience’.

I’ve not seen this discussed in the medical literature though, so if you know of any articles that do tackle it, I’d love to hear about them.

Link to PubMed entry for stair triggered epilepsy case.

Strange journeys of the mind

New Scientist has a fantastic issue on ‘strange journeys of the mind’ that has three great articles on the twilight zone of sleep, simulating psychopathology with hypnosis and laboratory-induced out-of-body experiences.

The piece on the hypnotic simulation of brain disturbances is fantastic, not least because it features two researchers I work with, Peter Halligan and David Oakley, who have done some of the seminal work in the area.

Essentially, the approach views hypnosis as a tool that allows researchers, with the co-operation of the participant, to temporarily alter mental states in a completely safe and reversible way.

Importantly, these alterations, such as blindness or paralysis, seem like they’re happening ‘on their own’ – which helps us understand conditions like conversion disorder, where these sorts of symptoms appear without any neurological damage but without the patient seeming to have any control over them.

The other article which blew me away was on recent studies suggesting that sleep and alertness are not two distinct states of consciousness and in some people with a dementia-like brain disorder the boundaries between sleep and wakefulness completely break down.

That this can happen contradicts the way we usually think about sleep, but it came as no surprise to Mark Mahowald, medical director of the Minnesota Regional Sleep Disorders Center in Minneapolis, who has long contested the dogma that sleep and wakefulness are discrete and distinct states. “There is now overwhelming evidence that the primary states of being are not mutually exclusive,” he says. The blurring of sleep and wakefulness is very clear in status dissociatus, but he believes it can happen to us all. If he is right, we will have to rethink our understanding of what sleep is and what it is for. Maybe wakefulness is not the all-or-nothing phenomenon we thought it was either.

Finally, the piece on out of body experiences covers the work of Swiss researchers who have been studying these states in people with brain disorder, and managing to induce them in volunteers in a number of inventive ways.

Three awesome articles, all worth your time, all open-access. Three cheers New Scientist.

Link to article on sleep states.
Link to article on hypnotic simulations.
Link to article on out-of-body experiences.

Spike at the end of the tunnel

Electrical readings from seven patients who died in hospital suggest that the brain undergoes a surge of activity at the moment of death, according to a study just published in the Journal of Palliative Medicine.

Palliative care is a medical approach that aims to make dying patients as comfortable as possible. As part of this, doctors from George Washington University Medical Centre’s intensive care unit were using standard alertness monitors for seven patients that include EEG measurements of the frontal lobes.

The monitors are commercial devices designed to help anaesthetists monitor how ‘awake’ patients are, and they combine the electrical readings from the brain into a single signal that reflects alertness.

For each of the seven patients, the researchers noticed that at the point where blood pressure dropped to zero there was a surge in brain activity. The graph on the right is from one of the patients and shows a typical activity burst.

This is not the first time these have been noticed, but previous reports were single cases and the electrical surges were explained away as due to electrical interference from other sources. In these new cases, the doctors could be pretty confident that previously suggested sources of interference weren’t present.

Instead, they suggest that the surge was due to ‘anoxic depolarisation’ – a process where the lack of oxygen destabilises the electrical balance of the neurons leading to one last cascade of activity.

Now, this is just a case series and the neuroelectrical measures aren’t the best. The researchers encourage more systematic research with appropriate tools, but they do suggest an intriguing hypothesis with regard to ‘near death experiences’:

We speculate that in those patients who suffer cardiac arrest who are successfully revived, they may recall the images and memories triggered by this cascade. We offer this as a potential explanation for the clarity in which many patients have “out of body experiences” when successfully revived from a near death event.

One of the difficulties, of course, is that although ‘near death experiences’ are a well-known phenomenon, we only know about them from people who weren’t really dying (or even from people who were never actually ‘near death’ as one of my favourite studies attests).

Nevertheless, neuroscience studies on the dying are likely to be of increasing interest especially as the debate about what counts as death become more prominent.

Link to DOI entry and summary of study.

Strung out on lasers

In what sounds like a plot from an animated sci-fi film, I’ve just found a remarkable study where Japanese researchers put a Yoga Master in a brain scanner and fired lasers at him because he claimed not to be able to feel pain while meditating.

It turns out that he showed significantly less brain activity in areas typically activated by pain when meditating.

Intracerebral pain processing in a Yoga Master who claims not to feel pain during meditation.

Eur J Pain. 2005 Oct;9(5):581-9.

Kakigi R, Nakata H, Inui K, Hiroe N, Nagata O, Honda M, Tanaka S, Sadato N, Kawakami M.

We recorded magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) following noxious laser stimulation in a Yoga Master who claims not to feel pain when meditating. As for background MEG activity, the power of alpha frequency bands peaking at around 10 Hz was much increased during meditation over occipital, parietal and temporal regions, when compared with the non-meditative state, which might mean the subject was very relaxed, though he did not fall asleep, during meditation.

Primary pain-related cortical activities recorded from primary (SI) and secondary somatosensory cortices (SII) by MEG were very weak or absent during meditation. As for fMRI recording, there were remarkable changes in levels of activity in the thalamus, SII-insula (mainly the insula) and cingulate cortex between meditation and non-meditation. Activities in all three regions were increased during non-meditation, similar to results in normal subjects. In contrast, activities in all three regions were weaker during meditation, and the level was lower than the baseline in the thalamus.

Recent neuroimaging and electrophysiological studies have clarified that the emotional aspect of pain perception mainly involves the insula and cingulate cortex. Though we cannot clearly explain this unusual condition in the Yoga Master, a change of multiple regions relating to pain perception could be responsible, since pain is a complex sensory and emotional experience.

I have an image of scientists shielding their eyes as lasers fail to penetrate the force field of the Yoga Master who serenely hovers a few inches above the ground, although I suspect that’s because I’ve read too many manga comics

Link to PubMed entry for study,

Blink outside the box

RadioLab has a brilliant short podcast on the psychological role of blinks, based on a study that found that when watching a film our blinks are remarkably synchronised.

The programme dispels the myth that blinking serves only to keep our eyes wet as apparently studies have shown that we don’t blink any more or less in different humidities.

Instead, it explores a fascinating new study that found that blinks became synchronised when watching a film of another person, but not when watching landscapes or listening to stories.

Interestingly, blinks seems to be controlled so they occur at the start and end of meaning actions.

This is from the study abstract:

Synchronized blinks occurred during scenes that required less attention such as at the conclusion of an action, during the absence of the main character, during a long shot and during repeated presentations of a similar scene. In contrast, blink synchronization was not observed when subjects viewed a background video or when they listened to a story read aloud. The results suggest that humans share a mechanism for controlling the timing of blinks that searches for an implicit timing that is appropriate to minimize the chance of losing critical information while viewing a stream of visual events.

Blinking helps us comprehend the world. I find that quite amazing.

We know that blinking is also tied to some quite fundamental functions of the brain. For example, the higher the amount of spontaneous blinking you do, the higher the amount of dopamine you produce in the striatum, a deep brain area.

This is also links to your ability to stop unwanted actions, with a recent study linking higher blink rates to slower stop times.

As always the RadioLab programme is gripping audio velvet. I really recommend some headphones and 15 minutes of undisturbed time to lose yourself.

Link to RadioLab short podcast ‘Blink’.
Link to full text of blink synchronisation study.

Night terrors and night terrorists

Earlier this year we covered a study on REM sleep behaviour disorder (RBD) where normal sleep paralysis breaks down and sleepers act out their dreams. The Journal of Forensic Science has just published a study on the dark side of the disorder, where affected sleepers experience nightmares and can unknowingly damage themselves or their partners in fits of dream world violence.

The researchers examined all the published cases on violence in REM sleep behaviour disorder with potential for a lethal outcome and found they fall into three groups: choking or headlock attacks, throwing someone or throwing yourself through a window, and diving from the bed.

Some of the descriptions are pretty intense:

A 63-year-old man with RBD and delayed-onset Shy-Drager Syndrome reported “a progressive 10-year history of abnormal behavior during sleep. He would at various times choke, kick, punch, and spit on his wife while he was asleep. In addition, complex behaviors such as getting out of bed and running into walls while asleep were reported by family members. This behavior occurred while the patient was dreaming, usually of being attacked.

A 67-year-old man had a 3-year history of progressive stiffness and slowing of his left side. Five years before the onset of these symptoms, he began having vivid dreams together with violent movements during sleep. Once he dreamed of being trapped in a house on fire, and he almost jumped out of the window, if not for his wife awakening and restraining him.

A 25-year-old woman with multiple sclerosis “presented with a 6-month history of sudden awakenings from fearful, often vivid‚Ä¶dreams and with terrified screams or violent behavior such as kicking, running to the door or to the window, crying and falling out of bed. If awakened, she always recalled a fighting dream. Once she repetitively banged her head against the floor, inducing a large facial hematoma. On that occasion, she was dreaming that a man was knocking her against the wall.

The idea that someone could be violent during sleep without any awareness was initially treated with suspicion but it has since been confirmed in sleep labs where patient are video-taped and wired up to an EEG to confirm they are in REM sleep.

There have now been numerous legal cases where ‘sleepwalking violence’ has been used as a defence for murders or attempted murders, and at least one case where it led to a successful acquittal.

Link to summary of RBD lethal violence study.

One nagging thing…

The BPS Research Digest has a fantastic feature where they’ve invited some of the world’s leading psychologists to discuss one nagging thing they still don’t understand about themselves.

Some take the challenge as a query about themselves as human beings, others about them personally, and the answers are a wonderful mix of the scientific and personal, the profound and ephemeral.

This is one of the many highlights, from social psychologist Norbert Schwartz, cursing his inability to detect his own biases:

One nagging thing I don‚Äôt understand about myself is why I‚Äôm still fooled by incidental feelings. Some 25 years ago Jerry Clore and I studied how gloomy weather makes one‚Äôs whole life look bad — unless one becomes aware of the weather and attributes one‚Äôs gloomy mood to the gloomy sky, which eliminates the influence. You‚Äôd think I learned that lesson and now know how to deal with gloomy skies. I don‚Äôt, they still get me. The same is true for other subjective experiences, like the processing fluency resulting from print fonts [pdf] ‚Äì I still fall prey to their influence. Why does insight into how such influences work not help us notice them when they occur? What makes the immediate experience so powerful that I fail to apply my own theorizing until some blogger asks a question that brings it to mind?

In fact, there are several pieces where psychologists gently bemoan their inability to apply their research findings to their own life, giving the series a slightly wistful feel.

Link to BPS Research Digest ‘One nagging thing…’ series.

Rubbish in the margin

One of the most influential and controversial papers in psychiatry was from a 1976 study published in The Lancet that found that people with schizophrenia had larger fluid filled ventricles in the brain.

Yesterday, I looked up the original paper in London’s Institute of Psychiatry library and was amazed to see that the controversy seems ingrained into the paper copy, which has been ripped, repaired, damaged and defaced.

In the early days of scientific psychiatry, during the 1800s, many famous German psychiatrists expended a great deal of effort examining the post-mortem brains of patients with schizophrenia (also known at that time as dementia praecox) attempting to demonstrate Wilhelm Griesinger’s theory that “all mental illness is disease of the brain.”

Despite numerous studies, they were unable to replicate the success of studies on dementia, which they linked to specific changes in the brain. So for generations, schizophrenia came to be defined as a condition in which the brain was structurally normal.

This fact was often highlighted by the antipsychiatry movement to suggest that ‘mental illness’ was nothing more than a difference in human experience and there was no medical evidence supporting the work of psychiatrists.

But the fact was also cited by many psychiatrists resistant to the relatively new wave of medications that had appeared on the scene. The drugs were claimed to ‘fix’ the brain with the assumption that the discovery of clear evidence for brain differences would just be a matter of time.

Enter Eve Johnstone and her colleagues at Northwick Park Hospital in London, who, in the midst of this politically charged environment, completed a study that compared CAT brain scans of 18 patients with schizophrenia to a group of healthy control participants. Alongside the scans, the researchers also tested the participants’ mental abilities with psychological tests.

The results were striking. They found the size of the ventricles, the fluid filled spaces in the brain, was, on average, larger in patients with schizophrenia and that it was correlated with the degree of difficulty with tests of memory, concentration and problem solving.

This caused enormous interest and controversy at the time. The paper copy from London’s Institute of Psychiatry library clearly reflects this, as it has been read so many times (and possibly ripped out) that it is virtually in tatters and has been reattached with sticky tape in an otherwise pristine copy of the journal.

There are a few annotations on the page, including the word “Rubbish” written in the margin!

Although seminal, the study has been rightly criticised and one of the major difficulties with these sorts of studies is that because patients are normally taking antipsychotic medication, it’s hard to distinguish where the effect is linked to schizophrenia or the treatment.

While some medication is thought to also thought to affect brain structure, a study on patients that have never taken medication seem to suggest some differences in ventricle size, on average, are still apparent.

The ‘on average’ bit is important though, as these differences are not present in everyone with the diagnosis. They’re just an average difference when you compare a group of people with and without schizophrenia. Furthermore, we’re still not quite sure of its significance.

So the topic is still as controversial as when Johnstone’s study first appeared in 1976, although the argument has shifted from whether differences in the structure of the brain are associated with schizophrenia, to whether they are telling us anything useful.

Link to scan of article from Institute of Psychiatry library.
Link to PubMed entry for same.

Lightning-induced robotic speech

I just found a curious case study of a man who developed ‘robotic speech’ after being hit by lightning. Rather than the “I am a Dalek!” style mechanical sound it seems to be more like the very. deliberate. and. exact. speech synthesis style, somewhat like Data from Star Trek the Next Generation

Lightning-induced robotic speech

Neurology. 1994 May;44(5):991-2.

To the Editor

Because of a recently observed case, I was intrigued by the communication of Cherington et al[1] concerning lightning encephalopathy. The authors referred to evidence by Critchley[2] that the cerebellum can be selectively injured in lightning-struck patients, Two of their there patients had signs of cerebellar dysfunction. MRI in one of their patients evidenced superior cerebellar atrophy.

The force of a lightning strike threw a 20-year-old roofer to the ground from the truck in which he was standing. Panicked, he immediately began to run. A numbness and weakness of his arms and back cleared after several days, but the more striking abnormality was a profound alteration of his speech, which he described as having become robotic. Each syllable was clearly enunciated with a slight pause between syllables, so that while the flow of his speech was slowed, he was able to communicate well. His speech was actually easier to comprehend than that of some normal persons. His brother had indeed complained that the patient’s premorbid speech had been too rapid and word-jumbled; that speech was transformed to robotic speech, with fine diction and super-clear enunciation. Each morning, his speech was “normal” until shortly after he began to talk, when it reverted to the robotic pattern for the remainder of the day. The neurologic examination was normal except for right upper extremity hypalgesia. Brain MRI was normal.

I considered his robotic-speech problem to be most like the “scanning speech” of cerebellar disease. I have found no references to similar cases, but the reports of selective cerebellar injury by lightning strike[1-3] lead-me to suspect that robotic speech maybe a more common sequel than has been recognized.

Gordan J. Gilbeft, MD
St. Petersbutg, FL

1. Cherington M, Yarnell P, Hallmark D. MRI in lightning encephalopathy. Neurology 1993; 43(7):1437-8
2. Critchley M. Neurological effects of lightning and electricity. Lancet 1934;1:68‚Äì72
3. Morocutti C, Spadaro M, Amabile G. TRH treatment in cerebellar ataxia following a lighting stroke. Ital J Neurol Sci 1989;10:531.

The original authors reply and seemed somewhat baffled, saying that it could equally arise from the shock of the experience rather than damage to the brain.

Link to PubMed entry for case study.

Do antidepressants cause mud flinging?

Prospect magazine has an interesting article covering psychologist Irving Kirsch’s widely publicised meta-analyses that have questioned whether Prozac-style SSRI antidepressants are any better than placebo.

Kirsch has become well known for requesting unpublished trial data via the US Freedom of Information Act and pooling it with the published evidence. The conclusion of his latest re-analysis was that there was little difference between sugar pills and SSRIs in the treatment of depression.

This has kicked up all sorts of merry hell, not least because the media reported (and the Prospect article implies) that ‘antidepressants don’t work’ which is clearly false. They do work, but the debate is over how much of the effect is due to placebo.

It’s not quite as simple as it seems of course, as not everyone agrees with Kirsch’s methods and, as noted in an insightful 2008 paper, his argument is based on the assumption that people who respond to antidepressants also respond to placebo in a similar way, when we know there are individual variations in both.

Kirsch apparently has a book coming out shortly which is likely to restart the debate and it’s likely to be heated.

There are some hints of this in the article where several prominent psychiatric scientists give variations on the “don’t criticise the evidence, you’re harming children!” argument. In fact, head of the NHS trust where my research institution is based apparently blames ‘the media, and psychologists’ “who have a vested interest in constantly attacking antidepressants”. Yes, we’ve reached that level already.

We went through a very similar process when concerns over whether SSRIs increased suicidal thinking in adolescents were raised. Lots of similar mud-flinging ensued.

Interestingly, a meta-analysis of suicide attempts and suicidal thoughts in 372 trials just published in the British Medical Journal found that overall SSRIs had no effect on risk of self-harm, and that when the data was divided by age, there was a slight increase in thoughts and attempt in people younger than 25 and a slight decrease in adults aged over 65 (the comments on the article are also worth reading).

It’s probably worth saying that even in young people self-harm when taking antidepressants is very rare, but the fact that the drugs had no overall protective effect except in older people should give us pause for thought.

But getting people to focus on the evidence when they’re wound up is like getting people to focus on the fire exits during a strip show. We all accept the importance of doing so but few can quite manage it when the time comes.

Link to Prospect article on antidepressants (via @researchdigest)

Anxiety, an unauthorised biography

The New York Times has an absolutely fantastic article on the psychology and neuroscience of anxiety and how an anxious temperament at birth can ebb and flow during our lifetime.

It’s an in-depth article that really does justice to the topic, looking at extensive research into our anxious states, but also carefully questioning some of the sloppy assumptions of many article where brain activity is described as directly representing mental states.

But having all the earmarks of anxiety in the brain does not always translate into a subjective experience of anxiety. ‚ÄúThe brain state does not make it a disorder,‚Äù Kagan told me. ‚ÄúThe brain state exists, and the statement ‚ÄòI‚Äôm anxious,‚Äô exists, and the correlation is imperfect.‚Äù Two people can experience the same level of anxiety, he said, but one who has interesting work to distract her from the jittery feelings might do fine, while another who has just lost his job spends all day at home fretting and might be quicker to reach a point where the thrum becomes overwhelming. It‚Äôs all in the context, the interpretation, the ability to divert your attention from the knot in your gut.

The article is incredibly well written and it tackles a huge range of topics in the understanding of fear and anxiety. Highly recommended.

Link to NYT article ‘Understanding the Anxious Mind’ (via @mocost)

2009-10-02 Spike activity

Quick links from the past week in mind and brain news:

<img align="left" src="http://mindhacks-legacy.s3.amazonaws.com/2005/01/spike.jpg" width="102" height="120"

USA Today has an interesting piece on how social networking sites are becoming research targets in health and psychology.

The oft-replicated finding in relationship research that, on average, women would be most hurt by romantic betrayal and men by sexual betrayal, is covered by Cognitive Daily.

New Scientist discusses a new imaging study that highlights the importance of the hippocampus in conceptual learning.

Love is a like a zoom lens, according to The Guardian. Sex is like a microscope, or an oscilloscope, depending on what you’re in to.

The New York Times has a piece on increased rates of dementia seen in American football players and how the NFL are trying to downplay the data.

Do people really lie three times within 10 minutes of meeting someone new? asks PsyBlog questioning the common statistic.

Time reports on a study finding that social comparisons with thin people who are big eaters can lead people to choose larger food portions.

Gamers are more aggressive to strangers, says New Scientist who clearly haven’t read the study which didn’t measure aggression to anyone.

Time magazine has another good article on how frequency of email contact can be modelled with a remarkable simple mathematical formula.

Religion protects against drug use in dance. Doping in ballroom dancing, who knew? (apart from Jesus)

Furious Seasons covers a new study finding that the majority of psychiatric drugs are prescribed by family doctors.

I wish I could be at the Encultured Brain conference, organised by the chaps from the excellent Neuroanthropology blog.

The Globe and Mail covers research on how women’s attitudes to their genitals is linked to orgasm frequency and health behaviour.

The development of implantable electronic <a href="Burst of Technology Helps Blind to See
http://www.nytimes.com/2009/09/27/health/research/27eye.html?em=&pagewanted=all”>retinas is covered by The New York Times.

Both the British and American psychology associations have just launched their respective history of psychology websites.

New Scientist covers an overly melodramatic promo video by charity Autism Speaks and the spoof videos by people with autism.

The limits of a universal view of mental illness are discussed by Frontier Psychiatrist.

Psychiatric Times has concluded a three part series on the science behind fMRI brain scanning experiments.

Can the right kinds of play teach self-control in children? asks The New York Times as it discusses a radically different approach to child behaviour.

BBC News reports on a new study of treatment for drug addicts in the UK and finds treatment programme successes are encouraging.

Anticipating an interaction with an obese person provokes feelings of social power, reports the BPS Research Digest.

The Neurocritic has a neurogasm which looks more like a shampoo bottle than a drink but Paris Hilton is having one so it must be science, right?

The interesting origins of the British Prime Minister on antidepressants so what poppycock is tackled by Neuroskeptic.

Colbert on snus and placebo

Stephen Colbert did a brilliantly funny piece on his show the other night, tackling the introduction of ‘snus‘ to the USA, tobacco pouches that fit under the lip, and the increasing placebo effect, a topic which we discussed recently.

Colbert tries the snus pouches on the programme, which, I have to say, seem remarkably uninviting, and riffs on the health benefits of sugar pills with plenty of laughs.

Link to Stephen Colbert clip (thanks Veronica!)

The insanity epidemic, 1907

I’ve happened upon an interesting snippet from the regular Nature “100 years ago” feature concerning a 1907 debate on whether insanity was really increasing or whether it just seemed that way due to changes in diagnosis and treatment methods.

It made me smile because it is almost exactly the same argument that is being had now about whether cases of autism are genuinely increasing or whether this just reflects changes in diagnosis and treatment methods:

Notwithstanding the much improved statistics recently issued by the Lunacy Commissioners, thoroughly satisfactory materials are still wanting for solving the question whether the prevalence of insanity is or is not increasing. The importance of the problem… imparts special interest to a paper by Mr. Noel A. Humphreys on the alleged increase of insanity… This paper shows in a striking manner the value of scientific statistics in checking crude figures.

The author expresses a decided opinion that there is no absolute proof of actual increase of occurring insanity in England and Wales, and that the continued increase in the number and proportion of the registered and certified insane is due to changes in the degree and nature of mental unsoundness for which asylum treatment is considered necessary, and to the marked decline in the rate of discharge (including deaths) from asylums.

From Nature 18 July 1907.

Link to Nature “100 years ago” snippet.
Link to Wikipedia page on epidemiology of autism.

Creative in love

The Scientific American Mind blog Mind Matters has a fantastic article on the links between love and creativity and how just thinking of a romantic relationship can have an immediate effect on creative thinking.

The piece covers several studies which have shown that love or the concept of love promotes a ‘big picture’ thinking style while thinking of a quick shag seems to do the reverse:

The clever experiments demonstrated that love makes us think differently in that it triggers global processing, which in turn promotes creative thinking and interferes with analytic thinking. Thinking about sex, however, has the opposite effect: it triggers local processing, which in turn promotes analytic thinking and interferes with creativity.

Why does love make us think more globally? The researchers suggest that romantic love induces a long-term perspective, whereas sexual desire induces a short-term perspective. This is because love typically entails wishes and goals of prolonged attachment with a person, whereas sexual desire is typically focused on engaging in sexual activities in the “here and now”. Consistent with this idea, when the researchers asked people to imagine a romantic date or a casual sex encounter, they found that those who imagined dates imagined them as occurring farther into the future than those who imagined casual sex…

A global processing style promotes creative thinking because it helps raise remote and uncommon associations.

Clearly there is a happy medium to be found here, and I have to say, “would you like me to balance your processing styles?” has the makings of a great chat-up line.

Link to Does Falling in Love Make Us More Creative? (via Frontal Cortex)

Side-effects from placebos can be drug specific

A fascinating study just published in the medical journal Pain examined the side-effects reported by patients taking placebos in clinical trials to test migraine drugs. It found that side-effects from placebo were almost as common as from the actual drug, but most interestingly, were specific to side-effects you would expected from the comparison medication.

In other words, the side-effects you get from a sugar pill in a study on anticonvulsant drugs closely resemble side-effects you get from anticonvulsants and are different from the side-effects you get from a sugar pill in a study on pain killers, which more closely resemble pain killer side-effects.

The researchers, led by neuroscientist Martina Amanzio, looked at trials for three type of migraine drugs: NSAIDs (like aspirin), triptans that work on the serotonin system, and anticonvulsant drugs more often used to treat epilepsy.

Side-effects from placebo are known as the nocebo effect and just the combined list of side-effects from the placebo groups in this study is surprising enough:

abdominal pain, anorexia or/and weight loss, attention difficulties, burning or/and flushing, chest discomfort, chills, diarrhea, dizziness, dry mouth, dyspepsia, fatigue, heaviness, injection side reaction, insomnia, language difficulties, memory difficulties, nasal signs and symptoms, nausea, numbness, paresthesia or/and tingling, pharyngitis, somnolence or/and drowsiness, stinging or/and pressure sensation, taste disturbance, tinnitus, upper respiratory tract infection, vomiting, weakness

It turns out that when placebo was being compared to an anticonvulsant, side-effects more common in these drugs – like fatigue, reduced appetite, sleepiness and tingling sensations – were more common in the placebo. In contrast, stomach upsets and dry mouth were more common in the placebo group when the comparison was with NSAID painkillers, which more often cause these symptoms themselves.

One explanation may be that before taking part in a clinical trial, patients are informed of the possible side-effects that the active drug may cause, regardless of whether they are going to be given placebo or the actual medication.

Information on the possible side-effects will be specific to the real medication, and, as we know that expectation plays a big part in the placebo effect, it is probably also shaping the nocebo effect and leading to the production of symptoms through expectancy.

Link to PubMed entry for study.