Walking zombie syndrome

wide_bw_eye.jpgAntonio Melechi explores one of the bizarre corners of the medical literature in his book Fugitive Minds (p211, ISBN 0099436272):

In 1979, the Journal of the Tennessee Medical Association announced that the ‘Walking zombie syndrome’ – a condition in which depression and withdrawal led individuals to unconsciously believe that they were dead – was on the increase. Illness, coma, high fever, operations performed under partial anaesthesia, and bereavement were, it claimed, just some of the situations through which a ‘death suggestion’ could be unwittingly assimilated.

Fortunately, there was, according to the hypnotherapists who ‘discovered’ the condition, one simple and effective cure: age regression. By returning patients to the event which triggered the ‘death suggestion’, the ‘symptoms of death’ could, it was claimed, be at once relived and remedied.

Although most physicians remained unaware of the diagnosis or treatment, the pseudo-illness continued to claim factitious casualties. By the late 1980s, the United States had apparently overtaken Haiti as the zombie capital of the world. According to one estimate, there were ‘thousands of walking zombies on the streets of every city’.

Link to PubMed entry for ‘The Walking Zombie syndrome in depressive disorders’.
Link to review of ‘Fugitive Minds’.

All in the Mind on sexual desire

girl_eyes_right.jpgABC Radio’s All in the Mind starts a four part series today on the emotional brain, with the first in the series examining the complexity of sexual desire.

Psychologists Dylan Evans and Doris McIlwain discuss whether we have one sex drive or many, and how it influences and gets tangled up with our other thoughts, desires and behaviour.

Despite the portrayal in some of the media, what emerges is that sexual desire is a rich and complex human motivator.

mp3 or realaudio or programme audio.
Link to transcript.

Did Mohammed have epilepsy?

Mohammed, founder of Islam, is often described as having epilepsy. He’s even described as such on epilepsy information site epilepsy.com. The historical basis for such claims are almost certainly false, however, and first stem from a historian writing almost 200 years after the Prophet’s death.

The myth has been most comprehensively debunked by the respected American historian of medicine Owsei Temkin in his book The Falling Sickness: This History of Epilepsy from the Greeks to the Beginnings of Modern Neurology (ISBN 0801848490). To quote from p153…

As is to be expected, the positive bias of Islam was countered by an opposite bias in the Christian world. As to the origin of the diagnosis “epilepsy”, everything points to Christian Byzantium, an empire that was no only hostile to Islam but at frequent war with the Arabs. Less than 200 years after Mohammed’s death, the Byzantium historian Theophanes (died about 817) told a story which was bound to make Mohammed appear and fraud and to discredit the belief in his divine mission.

According to Theophanes, Mohammed had the disease of epilepsy. And when his wife noticed it, she was very much grieved that she, being of noble descent, was tied to such a man, who was not only poor but epileptic as well. Now he attempts to soothe her with the following words: “I see a vision of an angel called Gabriel and not being able to bear the sight of him, I feel weak and fall down.” But she had a certain monk for a friend who had been exiled because of his false faith and who was living there, so she reported everything to him, including the name of the angel. And this man, wanting to reassure her, said to her: “He has spoken true, for this angel is sent forth to all prophets”. And she, having received the word of the pseudo-prophet, believed him and announced to the other women of her tribe that he was a prophet. (Theophanes, 1007, Chronographia, vol. 1, p334)

The is the story which was accepted by Western historians, theologians and physicians. The story has all the earmarks of religious and political propoganda. Hence it was repudiated by Gibbon as “an absurd calumny of the Greeks”.

PDF of Owesei Temkin’s obituary.

2005-11-25 Spike activity

Quick links from the past week in mind and brain news:

spike.jpg

Great new blog on combating stress, depression and addiction is now online and accepting new readers!

Singing for the Brain‘ shows remarkable results in helping people with Alzheimer’s communicate by using song.

Makes for a great story but probably best taken with a pinch of salt: Naked statue triggers mental imbalance, supposedly.

Emotional deprivation and neglect in childhood has long lasting effects on neurohormones. The Guardian also has the story.

Therapy for anxiety disorders can be successfully conducted over email.

People with mild symptoms of depression are better at perceiving details of their social environment than those who are not depressed.

Brain imaging study show ‘first ever’ images of stress in the brain.

People best able to filter out irrelevant information are better at remembering.

Relatives of people diagnosed with autism show similarities in brain structure and behaviour.

Tom Cruise’s on-air anti-psychiatry tirade recreated by talking aliens (via BoingBoing).

Through a scanner deeply

hypno_eye.jpgThe New York Times has an article on the increasing interest in hypnosis among cognitive neuroscientists, who are trying to understanding how suggestion and belief can affect basic mental processing.

The article describes some interesting recent work on hypnosis and perception, but omits some of the most fascinating experiments in this area.

A study published in 2003 involved hypnotising participants to simulate experiences of external control, akin to experiences sometimes found in psychosis, to discover whether similar brain areas might be involved in the psychotic and non-psychotic experiences.

Another study, published in the same year, involved hypnotising participants so they thought they were paralysed, in an attempt to better understand ‘hysterical’ paralysis, sometimes known as conversion disorder – a condition where paralysis is thought to occur due to psychological trauma rather than physical damage.

In these cases, hypnotised, non-hypnotised or ‘pretending’ participants were were asked to conduct actions while being brain-scanned, to compare and contrast active brain areas.

Interestingly, these two studies suggested that quite different brain networks were involved in producing the experiences, although both activated the cerebellum, a complex area, known to be involved in movement, but still largely mysterious.

Link to article ‘This Is Your Brain Under Hypnosis’.

Autistic pride

autism_pride_ribbon.jpgThe Observer has an article on the growing ‘autistic pride’ movement that aims to reframe autism as a variation of human experience with its own set of advantages and disadvantages, rather than as a neurological disorder that needs to be ‘cured’.

Many people with autism or Asperger’s syndrome describe people without such traits as ‘neurologically typical’ or NTs, based on the idea that autism might involve different brain ‘wiring’.

The autistic pride movement has found a natural home on the internet and several sites take a witty approach to making their point.

The Institute for the Study of the Neurologically Typical turns autism science on its head, by spoofing a research centre that examines non-autistic people as unusual or pathological.

The movement often places itself within a wider ‘neurodiversity‘ movement, demanding that society respects differences in brain structure and function, rather than always focusing on trying to ‘correct’ them.

The article also mentions the autism software project Reactive Colours, whose director, Wendy Keay-Bright, we interviewed back in July.

Link to Observer article ‘Say it loud, autistic and proud’.
Link to wikipedia article on autism rights movement.
Link to Institute for the Study of the Neurologically Typical.

Modern-day psychosurgery

neurosurgery.jpgAs a follow up to our previous post on the history of the now discarded practice of lobotomy, there’s been quite a bit of recent interest in the science and ethics of modern-day brain surgery in treating mental illness, a practice often known as ‘psychosurgery’.

BBC Radio 4 aired a one-off documentary called Brain Surgery to Cure the Mind, that discussed its history, practise and effects, including the use of ‘deep brain stimulation or DBS.

DBS involves implanting an electrode to increase or decrease activation in a certain brain area. It was pioneered for the treatment of Parkinson’s disease but early results suggest it may be useful in treating severe clinical depression. One advantage of DBS over other types of neurosurgery is that it is reversible.

An alternative type of brain surgery, used in both severe psychiatric illness and Parkinson’s disease, is to sever or remove a small area of brain thought to be involved in the causing the distress or impairment.

This latter form is particularly controversial, and the British Journal of Psychiatry has published a debate entitled ‘Should neurosurgery for mental disorder be allowed to die out?’.

A recent review of the scientific literature, based on psychiatric neurosurgery in Scotland details the evidence for the effectiveness of such treatments, what the most common forms of brain surgery involve, and the likely physical and cognitive risks.

Link to BBC ‘Brain Surgery to Cure the Mind’ (with audio).
Link to debate ‘Should neurosurgery for mental disorder be allowed to die out?’.
Link to article ‘Status of neurosurgery for mental disorder in Scotland’.

All in the Mind on epilepsy and altered states

small_epilepsy_image.jpgABC Radio’s All in the Mind has a special on epilepsy, examining the provision for epilepsy care in South Africa, and the link between altered states of consciousness and epileptic seizures.

The programme interviews Professor Bryan Kies from Groote Schuur Hospital in South Africa, and discusses the difficulties with dealing with epilepsy without access to newer, but more expensive medications, and the influence on traditional beliefs and how people with epilepsy are viewed.

Professor Michael Trimble, from the Insititue of Neurology in London discusses unusual experiences and altered states linked to epilepsy. Trimble has written extensively on the neuropsychiatry of epilepsy, particularly psychosis linked to epilepsy.

mp3 of realaudio of programme audio.
Link to transcript.
Learn to deal with an epileptic seizure.

Susan Clancy on significance of ‘alien abduction’

clancy_abducted_cover.jpgSusan Clancy’s recently published book Abducted: How People Come to Believe They Were Kidnapped by Aliens (ISBN 0674018796) details her five year research project into the psychology of self-confessed abductees, in an attempt to better understand unusual beliefs and experiences.

This quote is from the closing pages (p154-155):

The primary lesson I learned from my research with abductees is that many of us long for contact with the divine, and aliens are a way of coming to terms with the conflict between science and religion. I agree with Jung: extraterrestrials are technological angels…. We yearn for spiritualism and comfort, magic and meaning. As Bertolt Brecht said in his play Galileo, we need something “to reassure us that the pageant of the world has been written around us,…that a part for us has been created beyond this wretched one in a useless star.” Being abducted by aliens may be a baptism into the new religion of our technological age.

Link to article on Clancy’s work at Harvard.
Link to interview with Clancy on NPR radio.
Link to book information with 1st chapter online.
Link to article on ‘The Psychology and Neuroscience of Alien Abduction’.

SciAmMind on fear, eTherapy and Brian Wilson

SciAmMindNov.jpgA new issue of Scientific American Mind has hit the shelves, and with it comes two freely available articles on their website. One asking “Can We Cure Fear?” and the other on The Promise of eTherapy.

Other articles, only available in the print edition to non-subscribers, include one on the use of drugs to prevent long-term memories from forming, and another on regulating anger.

One other print-only article that particualarly caught my eye is supposedly on Brian Wilson, musical genius behind the Beach Boys.

I’ve only read the intro on the website so far, which states “Perhaps no story better exemplifies how mental illness can free up creativity, then crush it, than that of Brian Wilson”.

I’m hoping the article gets better than that, as Brian Wilson is perhaps one of the best examples of how someone can maintain their creative genius after severe mental illness, as the recent critically acclaimed ‘Smile‘ album and tour have proved.

Link to SciAmMind website.
Link to article ‘Can we cure fear?’.
Link to article ‘The promise of eTherapy’.

Personal story of lobotomy

howard_dully.jpgPublic radio station NPR has an interview with Howard Dully, who received a lobotomy when he was only 12 years old from controversial psychosurgery champion Walter Freeman.

Dully is shown on the left, holding one of Freeman’s operating tools that was used to punch through the bone just behind the eyes and sever the connections to the frontal lobes.

freeman.jpgFreeman (pictured right) was a complex character, as previously reported on Mind Hacks, who performed hundreds of lobotomies during his career.

Although psychosurgery is still performed to treat seemingly untreatable mental disorder, its use is now rare, unlike when it was championed for almost all forms of mental distress. It is still as controversial now as it was when it was in its heyday, however.

The inventor of the procedure, Egas Moniz, won a Nobel Prize for his work, now much to the embarrassment of many in the scientific community. This was only a few years before he was shot and paralysed by one of his ex-patients who resented Moniz’s work.

The website Lobotomy.info has a wealth of information about the procedure and its originators, including an excellent history entitled “Adventures with an Ice Pick“.

Link to webpage on NPR programme “My Lobotomy” (via BoingBoing).
mp3 of programme audio.
Link to lobotomy.info

2005-11-18 Spike activity

Quick links from the past week in mind and brain news:

spike.jpg

Twin study from the University of Amsterdam suggests a genetic contribution to loneliness.

What are we doing when we look away during a conversation? asks Cognitive Daily.

Brain differences found in relatives of people with autism.

Body image, not menopause, causes lack of desire in older women, argues Petra Boyton.

Interview with Leslie Savan on the influence of advertising and media speak on the style and structure of popular language.

Review of neuroscience studies suggests that adolescents are neurologically more vulnerable to addictions.

Nature reviews Nancy Andreasen’s new book “The Creating Brain: The Neuroscience of Genius”.

Friend-of-a-pharmacist

pill_spill.jpgThe New York Times has an article about the increasing willingness of young people to ‘prescribe’ themselves, and their friends, psychiatric drugs:

For a sizable group of people in their 20’s and 30’s, deciding on their own what drugs to take – in particular, stimulants, antidepressants and other psychiatric medications – is becoming the norm. Confident of their abilities and often skeptical of psychiatrists’ expertise, they choose to rely on their own research and each other’s experience in treating problems…

Perhaps, this is a curious result of consumer cynicism about the links between the pharmaceutical industry and the medical profession.

Drug marketing, in the USA at least, can be legally targeted at consumers, rather than at doctors only. Much of the marketing gives the impression that medications are low-risk and widely beneficial, when the reality can be far more complex.

Despite the fact that many psychiatric drugs can be of great value in treating mental distress or impairment, most will cause some form of side-effect and many are still without evidence of their long-term safety.

Rather than distrusting the pharmaceutical industry, which is usually cited as having an untoward influence on medical practice, young self-confident consumers may have, ironically, fallen for the ‘pill for every ill’ marketing hype and focused their cynicism largely on the medical profession.

Link to reg free NYT article ‘Young, Assured and Playing Pharmacist to Friends’ (via BrainBlog).

BBC Material World on creativity

white_lightbulb.jpgBBC Radio 4’s science programme The Material World has just had a special on the nature of creativity, how it can be defined, measured and encouraged.

The programme discusses the differences between artistic and scientific creativity, and whether creativity necessarilly has to be productive.

The first part of the programme is on nuclear fission, so skip to 13 minutes if you just want the section on creative thought.

Link to webpage of The Material World edition on creativity.
Realaudio of programme.

Keeping tabs on the english language

whisper_ear.jpgLanguage Log is a site that keeps track of language science, and the changes in the subtleties of language use.

It’s updated daily, and discusses everything from curious new uses of words to archaelogical findings that shed light on the early development of language.

One of my favourite long-running themes is spotting what Language Log have called ‘snowclones‘.

A snowclone is a popular sentence structure which is recycled and adapted from the original quote by replacing key words.

For example, “On the internet, no-one can hear you scream” is a snowclone of the original movie tag-line “In space, no-one can hear you scream.” Of course, it could be endlessly recycled by replacing ‘space’ with whatever comes to mind.

I am guessing the name ‘snowclone’ is an allusion to the American ‘snowcone’ frozen deserts desserts, which consist of plain crushed ice to which flavour is added.

I, for one, welcome our new snowclone overlords.

Link to Language Log
Link to snowclone definition.

Meditation can alter structure of the brain

siddharta.jpgA recently reported brain-scanning study has found evidence that sustained meditation alters the physical structure of the brain by increasing the thickness of the grey matter.

The researchers, led by neuroscientist Sarah Lazar, scanned the brains of 20 people with long-term experience of meditation, and compared them with 20 other, non-meditating people.

Brain regions associated with attention, sensation, perception and monitoring the body’s internal state were thicker in meditation participants than in the comparison group.

There is now increasing evidence – in line with a 2000 study, that reported that London Taxi drivers may have a larger hippocampus (an area of the brain known to be crucial for navigation), that mental practice may alter the brain’s structure on a relatively large scale.

Update: Grabbed from the comments page… Some cautionary words on interpreting ’cause’ from this sort of study (Thanks ‘Coffee Mug’!):

The only way to say that meditation can alter the structure of the brain would be to do a longitudinal study following people who hadn’t chosen to meditate prior to the study. Otherwise you run into the same problem as you did with the London cabbie study. Correlation is not causation. People born with bigger hippocampi might self-select as cab-drivers. People with bigger ‘attention centers’ might be more predisposed to get into meditation.

Link to write-up from LiveScience.
Link to scientific paper abstract.