vaughanbell

Case Notes epilepsy special and Wada musings

Just in case you’re still looking for ways to mark National Epilepsy week, a recent edition of Case Notes had a special on epilepsy, outlining the science and impact of this curious condition.

In one particularly interesting section, they discuss research on using neuroimaging to replace the Wada test – the procedure where the barbiturate drug sodium amobarbital is injected into the carotid artery to temporarily disable one hemisphere of the brain.

This is used in people about to undergo neurosurgery to remove a brain area that may be causing uncontrollable and dangerous epileptic seizures.

It is particularly important to know which hemisphere of the brain is most involved in language, so the surgeons know where to tread carefully to make sure the patient’s language ability isn’t damaged.

Obviously, injecting strong sedative drugs directly into major brain arteries has its risks; both to the patient (there is a small risk of stroke), and the clinicians – such as the occasional patient going bezerk on the drugs.

This has led researchers to try and replace the Wada test with something less invasive and somewhat safer, namely scanning the brain with fMRI (e.g. see this pdf).

The technology is still being developed, however, as the results of the Wada test and an fMRI scan don’t always match, although new developments are improving the accuracy of these brain scan techniques as time goes on.

Link to webpage on Case Notes special on epilepsy.
realaudio of programme.
Link to information on the Wada test from epilepsy.com

Five minutes with neurosurgeon Katrina Firlik

Neurosurgeon and author Dr Katrina Firlik has kindly agreed to answer a few questions about her interest in brain surgery and neuroscience.

She also tells me that her new book (featured previously on Mind Hacks) has been released in the UK under the name Brain Matters (ISBN 0297848070).

Apparently, she will be in the UK to talk about her work in the near future, so we’ll post details as soon as we know them.

Anyway, on to the interview…

Continue reading “Five minutes with neurosurgeon Katrina Firlik”

Developing Intelligence on the seven sins of memory

The first part of a series on memory failures has just appeared on the increasingly compulsive cognitive science blog Developing Intelligence.

The site is run by cognitive neuroscientist Chris Chatham who summarises the ‘seven sins of memory’ – Daniel Schacter’s famous description of the seven ways in which memory can become distorted or degraded.

Schacter first described his ideas in a landmark paper and later in an accessible book of the same name.

Chris has a different approach, however, and will be setting out his alternative views over the coming week:

In contrast to Schacter‚Äôs ‚Äúseven sins of memory‚Äù (1999), I argue that all types of memory inaccuracy arise from three distinct types of memory system failure: those of maintenance, of search, and of monitoring. Failures of maintenance include problems involving prospective memory (‚Äúforgetting to remember‚Äù), rapid forgetting, and absent-mindedness. Failures of search include retrieval-induced forgetting, tip-of-the-tongue phenomena, and amnesia. Failures of monitoring include source misattribution, memory biases, and suggestibility. Finally, other memory inaccuracies may actually result from interactions among multiple sources of failure.

In this week’s upcoming posts, I will review each of these categories of memory failure in turn, and describe how they can account for all types of memory inaccuracy when taken together.

Link to post at Developing Intelligence.

Dread pool

Neurofuture has collected a range of recent posts that have been inspired by recent research on the ‘neurobiological basis of dread’, although a particularly clear description of the study posted to Brain Ethics is, perhaps, a good one that’s missing.

The research was probably best summarised in the mainstream media in an article from Science.

The New York Times had slightly different angle on the story and asked the researchers about how you would go about avoiding feelings of dread.

The first study ever to look at where sensations of dread arise in the brain finds that contrary to what is widely believed, dread does not involve fear and anxiety in the moment of an unpleasant event. Instead, it derives from the attention that people devote beforehand to what they think will be extremely unpleasant.

So the solution to dread, the researchers say, is self-distraction.

Link to abstract of original scientific paper.

National epilepsy week focus on children

UK education and support charity Epilepsy Action has launched this year’s National Epilepsy Week, running from 14th-20th May.

The theme of the 2006 event is children and young people and the charity is focusing on encouraging schools to maximise the potential of pupils with epilepsy.

In a recent survey, only 19% of schools felt that staff knowledge of epilepsy was good.

Consequently, Epilepsy Action has produced a raft of information to support parents and teachers in their care of affected pupils, including an online guide: Essential Information for Teachers.

Even if you’re not involved with children or schools you can learn how to help someone who has a seizure. You could save their life.

Link to information on National Epilepsy Week.
Link to Essential Information for Teachers.
Link to first aid for seizures.

Another day in the frontal lobe

Katrina Firlik is a neurosurgeon. She’s one of the few female neurosurgeons in a largely male dominated profession and has written a book about her work and experiences called Another Day in the Frontal Lobe.

She’s recently been featured on numerous radio programmes and newspaper interviews (listed here), the best of which is probably an in-depth discussion about her work on an NPR radio show entitled A Surgeon’s-Eye View of the Brain.

A short excerpt of her book is available online:

The brain is soft. Some of my colleagues compare it to toothpaste, but that’s not quite right. It doesn’t spread like toothpaste. It doesn’t adhere to your fingers the way toothpaste does. Tofu — the soft variety, if you know tofu — may be a more accurate comparison. If you cut out a sizable cube of brain it retains its shape, more or less, although not quite as well as tofu. Damaged or swollen brain, on the other hand, is softer. Under pressure, it will readily express itself out of a hole in the skull made by a high-speed surgical drill. Perhaps the toothpaste analogy is more appropriate under these circumstances.

The issue of brain texture is on my mind all the time. Why? I am a neurosurgeon. The brain is my business. Although I acknowledge that the human brain is a refined, complex, and mysterious system, I often need to regard it as a soft object inhabiting the bony confines of a hard skull. Many of the brains I encounter have been pushed around by tumors, blood clots, infections, or strokes that have swollen out of control. Some have been invaded by bullets, nails, or even maggots. I see brains at their most vulnerable. However, whereas other brain specialists, like neurologists and psychiatrists, examine brain images and pontificate from outside of the cranium, neurosurgeons boast the additional manual relationship with our most complex of organs. We are part scientist, part mechanic.

She’s also an obvious neuroscience geek and has an online gallery of neuroanatomy drawings and a Cafepress store where you can buy t-shirts with them on!

Link to interview and discussion on NPR radio.
Link to Katrina Firlik’s website with book details.

Neuroweapons

More neurologisms abound, as Zack Lynch posts about a recent conference on ‘neuroweapons’.

In a previous post, he mentioned concerns about neurowarfare – the use of weapons that target the human central nervous system.

Presumably this means nerve agents, neurotoxins and the like, rather than simply being bashed on the head with a rock (perhaps, the earliest example of a neuroweapon?).

However, the more recent discussions seem to focus on the use of technology and drugs to enhance the cognitive function of soldiers and other military personnel.

Link to Brain Waves post on neuroweapons.

2006-05-12 Spike activity

Quick links from the past week in mind and brain news:

The New York Times examines the factors that contribute to exceptional talents and ‘expert performance‘.

Cognitive Daily analyses research that shows that hypnotism can abolish the Stroop effect.

New Scientist reports that women can pick out which men are child-friendly by looking at their faces. See also pdf of scientific paper. (via BB).

People with autism show different brain activity during resting or ‘day dreaming’ times than others, reports brain-imaging study.

Nobel-prizewinning neuroscientist Eric Kandel is profiled by The Loom’s Carl Zimmer. With audio interview and sample chapter of Kandel’s memoir.

Coventry University starts a two-year postgraduate degree course in parapsychology (via anomalist)

BrainEthics looks at the contribution of genetics to cognition, inspired by a special issue on the topic from the journal Behavior Genetics.

YouTube video of newly developed android woman!

Psychoanalysis at the Institute of Contemporary Arts

London’s swanky Institute of Contemporary Arts has an ongoing series of “psychoanalytic exploration of films representing various forms of psychopathology and other emotional conditions”.

It’s been happening for a while and seems to be an ongoing project, but had totally passed me by.

Films are shown, and then discussed by members of the Institute of Psychoanalysis to try and better understand the social meaning of the movie and motivations of the characters.

The next film is Roman Polanski’s Repulsion, to be shown Sunday 14th May.

‘Send in the Idiots’ author interviewed on NPR

Kamran Nazeer, author of a new book on being a child in a school for kids with autism, called Send in the Idiots, is interviewed on NPR radio.

Nazeer was mentioned earlier this week on Mind Hacks, and there’s some commentary and ongoing discussion about the interview on a post over at Autism Diva’s blog.

Link to NPR interview with Kamran Nazeer.

Trephination set on EBay

Someone has an EBay auction about to close in which they’re selling a genuine set of surgical tools for trephination – the surgical practice of drilling holes through the skull.

The practice, also known as trepanation or trepanning, has been carried out since ancient times and has been thought to cure all sorts of conditions we would now know as mental or neurological disorders – such as epilepsy or psychosis.

It is thought that it was carried out to release ‘evil spirits’ or similar from the head, by creating a way for them to escape.

The practice hasn’t died out, however. It is occasionally practised by peoples outside the reach of modern medicine, and some people in industrialised countries do it as a form of body modification for its supposed consciousness modifying properties.

In fact, there’s a whole trepanning subculture on the internet.

For example, the Body Modification EZine has an article about someone who undertook a trepanning procedure (warning, if you’re a bit squeamish, the article and images are a bit icky):

I awoke the next morning still very much wanting to move forward with the operation. I thought to myself, “The key to more consciousness is sitting in the next room over. How can I know this and not unlock the door?” I explained my sincere desire to my girlfriend, and though she was still apprehensive, she agreed to try to be there for me if it was really what I wanted to do.

We had coated every wall of a room in plastic sheeting, had a placement tray ready (a sterilized tray to set the instruments on), had the drill sterilized and ready to go, autoclaved bits set out, etc and proceeded to trepan me. One person was to do the drilling and another was to help by passing instruments, turning the drill off and on, by holding a light in the right place at the right time, and by irrigating the wound every so often.

UPDATE: Grabbed from the comments page (thanks Anders!)…

Personally I need trepanation like I need a hole in my head (sorry,couldn’t resist), but there is actually a trepanation advocacy group called ITAG their site is at www.trepan.com (Warning: site uses excessive amounts of flash, a possible side effect of trepanation?) which has documents and videos on the procedure and it’s supposed benefits that are both enlightening and a little scary.

Link to auction on EBay (via BoingBoing).
Link to Wikipedia article on trepanation.
Link to BMEZine article on trepanation procedure.

NewSci on human optimisation

New Scientist has had a run of neuroscience-related articles recently, and this week’s cover story is no exception as it looks at developments in the science of human enhancement.

For those seeking that advantage, more opportunities are just around the corner – a lot more. Around 40 cognition-enhancing drugs are in development right now, designed to improve wakefulness, attention, memory, decision making and planning (see “Smarter minds”). Gerontologists are starting to believe we could directly intervene in the process of senescence to significantly increase the average human lifespan.

There have also been rapid advances in brain-machine interfaces, such as retinal implants, communication devices for paralysed and locked-in patients, and even memory prostheses, hinting at the possibility of neural implants that enhance normal functioning. Progress in genetic engineering and gene therapy suggests that we will soon be able to rewrite our own genetic code, and that of future generations, removing broken genes, correcting errors and even inserting new ones…

Unfortunately, not available online unless you’re a subscribed, unfortunately, but your library shop or library should have a copy kicking around.

Link to table of contents.

Experimenting with theatre

The Soho Theatre in London’s West End hosts an event on Monday 15 May where a production will be staged after several days of intense collaboration between scientists and writers, exploring the theme that both science and theatre are essentially driven by experiment.

The event is being run by Tassos Stevens, who did his PhD in developmental psychology before moving on to theatre production.

He’s since been keen to integrate the two fields, and hopes to illustrate and explore a scientific experiement as part of the production.

There’s also a blog with an ongoing discussion about the project for those not able to see the production in person.

Link to details of event at London’s Soho Theatre.
Link to blog with ongoing discussion.

Solaris and the philosophy of consciousness

Stanislaw Lem was a reknowned science fiction writer. It is less known that his books are repleat with carefully thought out philosophy about the nature of consciousness and knowledge acquisition.

ABC Radio National’s The Philosopher’s Zone recently had a special examining Lem’s view on consciousness as demonstrated in his richly descriptive sci-fi works.

The novel Solaris has as a central plot, something not unfamiliar to readers of science fiction, and is replicated in many novels, and that is the notion of first contact with a completely alien intelligence. We have a central protagonist, Chris Kelvin, who goes to a space station that is orbiting a planet, Solaris, and has been orbiting this planet for hundreds of years. So by the time the novel begins the planet has been well known and it’s been the subject of scientific inquiry for over 100 years, and hundreds of volumes have been written about this planet, because it has a peculiar being inhabiting it, which is the ocean that covers most of the planet seems to be sentient, seems to be a rational being, but something completely different from anything else that human beings have encountered.

As the novel progresses, we realise that the inhabitants of the space station have all gone crazy or have died because of their continued proximity with this alien being. And our hero of course, Kelvin, and listeners who have seen either the Tarkowski film or the more recent film, will know that one of the peculiarities of this plasmatic ocean, as Lem calls it, is that it produces replica human beings, that it seems to have sourced from the deepest submerged memories of the scientists on board the space station.

mp3 or realaudio of programme.
Link to transcript.

Autism podcast

We seem to be on a run of autism news lately, and here’s one more to add to the list. I’ve just discovered AutismPodcast.org that has regular podcasts about autism science, parenting and people.

The most recent programme has an interview with Autism Diva who has been diagnosed with Asperger syndrome herself, has both a child with autism and a neurotypical child to keep her busy. She talks about her own experience of Asperger’s and her view on the current state of understanding the condition.

Autism Diva also runs a popular autism blog which we featured previously on Mind Hacks, that keeps tabs on the science and politics of the autism world.

The host of Autism Podcast is a father of a boy with autism, and obviously has a wide interest, as the archive of past programmes demonstrates.

Link to Autism Podcast.

Autism in the London Review of Books

London Review of Books has an in-depth review of two recently released books on autism: Laura Schreibman’s The Science and Fiction of Autism and Kamran Nazeer’s Send in the Idiots.

The author of the review, philosopher Ian Hacking (picture on the right), starts with some controversial views on autism.

Autism is devastating ‚Äì to the family. Children can be born with all manner of problems. Some begin life in great pain that can never be relieved, but at least there is a child there. An autistic child ‚Äì and here I am talking about what’s known as core autism ‚Äì is somehow not there. ‘Nobody Nowhere’, as the title of Donna Williams’s autobiography (1992) has it. Very often physically healthy (though there is a high incidence of other problems) he ‚Äì and it is usually he ‚Äì just does not respond. It is not merely that he does not learn to speak until years after his peers, and then inadequately. He has no affect; he never snuggles. He is obsessed with things and order, but does not play with toys in any recognisable way, and certainly does not play with other children. He mercilessly repeats a few things you say. With no comprehension. He has violent tantrums, not the usual sort of thing, but screaming, hitting, biting, smashing. This alternates with a placid gentleness, maybe even a smile ‚Äì but not really for you. Serious Down‚Äôs syndrome is pretty bad too, but despite all the difficulties, physical and mental, there is a loving little child there.

He admits that his views will make many parents angry. Indeed, they represent one of the most emotive debates in the field and centre around the question of whether autism is a disabling disease, or simply another way of experiencing the world.

Those who would argue against Hacking (often autistic people themselves) suggest that the self-absorption and social disinterest often shown by those with autism is considered a disease because of parent’s own dissatisfaction with their child’s unusual behaviour, rather than out of any genuine concern for the person themselves.

In it’s most polarised form, autistic people are being labelled as diseased while parents are accused of being selfish. It is not difficult to see why tempers flare.

The debate is complicated by the wide spectrum of behaviours labelled as autistic. A person diagnosed with autism may be someone who can’t look after themselves and needs constant assistance, or a slightly awkward yet top-of-their-field professional.

Indeed, Kamran Nazeer himself was diagnosed with autism as a child, and recounts his experiences and follows up his classmates in his book Send in the Idiots. One law degree and PhD later, he’s a policy adviser for the government.

The author of the other book, Professor Laura Schreibman, is a psychologist who works with people throughout the autism spectrum, from the most impaired to the most able.

Hacking obviously has a good knowledge of the science of autism, and does the reader the courtesy of making his own position clear early on, was well as making some insightful points about the books in question.

Link to review in London Review of Books (thanks tallapul!).