Spike activity 10-06-2016

Quick links from the past week in mind and brain news:

The New York Times has a fascinating piece on the online community of people who believe they are being ‘gang stalked’.

Completely destroy the immune system with chemotherapy and rebuild it with stem cells. A radical experimental treatment that seemed to halt multiple sclerosis with 1 death in 23 out of 24 patients people. One died. Reported by BBC News.

Aeon has a piece on the social function of human sacrifice.

Using image processing to improve reconstruction of movies from brain activity. Remarkable but trippy extraction of video from brain activity from Jack Gallant’s lab. Deep dream esque.

The Washington Post has an interesting piece on the history of seeing racism as a mental illness and its problems.

A New Theory Explains How Consciousness Evolved. The Atlantic has a good piece on Attention Schema Theory.

Mosaic has an excellent balanced piece on the effect of screens, smartphones and devices on young people.

There’s a good obituary for recently deceased legendary psychologist Jerome Bruner in The Washington Post.

Time reports that most violent crimes are wrongly linked to mental illness.

The widely-reported link between older fathers, spontaneous DNA mutations in sperm, and chance of offspring with autism may be due to a confound: men who carry risk factors tend to have children late in life. Good reporting from Spectrum.

The cognitive science of how to study

CC Licensed image from Flickr user Moyan Brenn. Click for source.Researchers from the Bjork Learning and Forgetting Lab at UCLA have created a fantastic video on the cognitive science of how to study.

Despite the fact that we now know loads about what makes for optimal learning, it’s rarely applied by students who are trying to learn a subject or ace a test.

This is a short, clear, helpful video on exactly that.

It looks like the video is set so it can’t be embedded but you can watch it at the link below.

Happy studying.
 

Link to Pro Tips: How to Study on vimeo

Twenty years, one Saturday

If you’re in the UK this Saturday, London’s Institute of Cognitive Neuroscience is celebrating 20 years of peering into the brain with an all-day £5 conference that gathers leading researchers to cover everything from the neuroscience of cannabis to embodied cognition.

By looking at the talks (warning: pdf format programme), it seems they’re pitched half way between BBC documentary and academic talk, so if you are suitably caffeinated, they should perfectly hit the spot.

You can buy tickets online but if you’re not walking through central London trying to pipe energy drinks directly into your bloodstream at 9.30am on Saturday, you can watch it via a livestream which is being hosted on the information superhighway.

Can’t wait.

 

Link to Mind the Brain conference details.

Suzanne Corkin has left the building

Neuropsychologist Suzanne Corkin, most well known for her work with profoundly amnesic patient HM, has passed away and The New York Times has a fitting obituary and tribute.

Although Corkin did a range of work on memory, including testing various medications to treat Alzheimer’s disease, she is in many ways synonymous with amnesic Patient HM, later revealed to be Henry Molaison, who she studied and worked with for most of both of their lives.

Corkin not only took a scientific interest in HM, she also ensured his well-being and appropriate care.

HM had perhaps one of the profoundest amnesias reported in the scientific literature but there is a lovely description in The New York Times obituary that describes how HM formed an emotional memory of Corkin, even though a conscious memory wasn’t present.

But it was her relationship with H.M. that was defining. His profound deficits made their relationship anything but normal — every time she walked in the room, she had to reintroduce herself — but that repetition bred a curious bond over time.

“He thought he knew me from high school,” Dr. Corkin said in an interview with The New York Times in 2008.

 

Link to Suzanne Corkin obituary in The NYT.

Spike activity 28-05-2016

Quick links from the past week in mind and brain news:

One of the earliest hominin constructions ever found hundreds of metres deep into a cave. Fascinating piece in The Atlantic.

Aeon has a fascinating piece on how we come to have knowledge of our own minds.

PET brain metabolism linked to return of consciousness in vegetative state patients. The ‘predict’ headline on the article is a bit misleading in everyday terms – it’s only one study so not good enough evidence to make clinical predictions – but fascinating work covered by Stat.

The Guardian has a piece on psychology’s study pre-registration revolution.

ABC Radio’s The Science Show has an excellent hour-long tribute to Oliver Sacks – in his own words.

How do we choose a romantic partner? Interesting review of studies from The Conversation.

Social Minds has a fascinating post on arguing that it’s about time we identified cognitive phenotypes for the social deficits in autism.

The science of the Psychoactive Drugs Act

The world’s stupidest drugs law, the Psychoactive Drugs Act, has come into effect in the UK last week and it claims to prohibit the creation and supply of all psychoactive substances not already covered by pre-existing drugs laws.

Apart from taking us further down the futile road of prohibition it is premised on something that’s scientifically impossible – testing if a seized drug is psychoactive from looking at its chemical structure.

The government claimed that they had ‘solved’ this problem and they’ve just released their forensic strategy document which, unsurprisingly, doesn’t actually solve it.

What it does do, however, is worthy of attention as it likely raises a whole new set of problems.

We learn from the forensic strategy that the test for ‘psychoactivity’ is to submit mystery substances to receptor binding assays – a lab test where the substance is added to cells ‘in a dish’ which have receptors for certain neurotransmitters to see if substances bind to and activate the receptors.

Your brain has many, many different forms of receptors, so the government has defined a list that will supposedly indicate whether a substance is ‘psychoactive’ based on whether a substance binds to and activates one of the following:

  • CB1 (targeted by cannabis and synthetic cannabinoid type drugs)
  • GABAA (targeted by benzodiazepine type drugs)
  • 5HT2A (targeted by hallucinogenic type drugs – these can be from a number of different types of drugs)
  • NMDA (targeted by dissociative/hallucinogenic drugs e.g. ketamine)
  • µ-opioid (targeted by opioid drugs e.g. heroin) and
  • monoamine transporters (targeted by stimulant drugs e.g. MDMA, cocaine).

These are indeed receptors that facilitate some of the major recreational drug groups but this is not an adequate definition of ‘psychoactivity’ not least because there are several psychoactive substances that don’t affect these receptors.

Most notable is long-running ‘legal high’ salvia divinorum which is wildly hallucinogenic but has its effect through the non-listed κ-opioid receptor.

So produce a lab-based tweak on the salvinorin A molecule, the ‘active ingredient’ in Salvia, and you have something that won’t be picked up by government tests.

The main problem though, is likely to be that these tests will be over-inclusive. Lots of substances will activate these receptors without having a psychoactive effect.

For example, epinastine is a drug in eye drops that strongly activates the 5HT2A in the lab but which doesn’t have a psychoactive effect because it doesn’t cross the blood-brain barrier.

Acamprosate is a drug used to treat alcoholism, not typically considered to be psychoactive, and yet activates GABAA receptors.

There are many more examples and they’re not hard to track down – mainly because we now have several open databases of drugs and receptor interactions so you can easily find psychoactive drugs that will screen negative or non psychoactive ones that will be falsely detected as mind-altering.

In practice, what this means is that lots of substances – chemicals from the home, the workshop, the lab, and the pharmacy – may screen for ‘psychoactivity’ but not be psychoactive. False positives, in other words.

But this approach also shows that the Psychoactive Drugs Act fails at solving the problem it is meant to overcome: underground labs producing new substances faster than they can be added to a list of banned drugs.

The Act just complements a fixed list of banned drugs with a fixed list of banned drug effects – making it just another target for grey market labs to innovate around.

What’s also interesting from the list is what drug effects are not proscribed – and we can probably expect underground innovation in pure D2 dopamine agonists that don’t affect monoamine transporters for uppers, and antihistamines as downers, among others. Although to be honest, most will likely just keep on using the same substances.

But considering that the biggest take home from ‘legal highs’ is that they were much worse for your health than ‘illegal highs’ – perhaps the best public health result we can hope for is that the Psychoactive Drugs Act pushes recreational drug users back to using the less harmful classics – speed, MDMA, weed and so on.

And when that’s the best you can hope for, you really know that your drug laws are in a dismal state.

A new wave of interrogation

Wired has an excellent article that tracks the development of police interrogation techniques from the dark days of physical violence, to the largely hand-me-down techniques depicted in classic cop shows, to a new era of interrogation developed and researched in secret.

It’s probably one of the best pieces you’ll read on interrogation psychology for, well, a very long time, because they don’t come around very often. This one is brilliantly written.

One key part tracks the influence of still-secret interrogation techniques from the US Government’s High-Value Detainee Interrogation Group or HIG as they have filtered through from the ‘war on terror’ to civilian law enforcement.

In 2010, to make good on a campaign promise that he would end the use of torture in US terror investigations, President Obama announced the formation of the High-Value Detainee Interrogation Group, a joint effort of the FBI, the CIA, and the Pentagon. In place of the waterboarding and coercion that took place at facilities like Abu Ghraib during the Bush years, the HIG was created to conduct noncoercive interrogations. Much of that work is top secret. HIG-trained interrogators, for instance, are said to have questioned would-be Times Square bomber Faisal Shahzad and convicted Boston Marathon bomber Dzhokhar Tsarnaev. The public knows nothing about how those interrogations, or the dozen or so others the HIG is said to have conducted, unfolded. Even the specific training methods the HIG employs—and that it has introduced to investigators in the Air Force, Navy, and elsewhere—have never been divulged.

At the same time, however, the HIG has become one of the most powerful funders of public research on interrogations in America.

A fascinating and compelling read.

 
Linked to Wired article on the new wave of interrogation.

Reconstructing through altered states

Yesterday, I had the pleasure of doing a post-screening Q&A with the film-makers of an amazing documentary called My Beautiful Broken Brain.

One of the many remarkable things about the documentary is that one of the film-makers is also the subject, as she began making the film a few days after her life-threatening brain injury.

The documentary follows Lotje Sodderland who experienced a major brain haemorrhage at the age of 34.

She started filming herself a few days afterwards on her iPhone, initially to make sense of her suddenly fragmented life, but soon contacted film-maker Sophie Robinson to get an external perspective.

It’s interesting both as a record of an emotional journey through recovery, but also because Lotje spent a lot of time working with a special effects designer to capture her altered experience of the world and make it available to the audience.

I also really recommend a long-form article Lotje wrote about her experience of brain injury for The Guardian.

It’s notable because it’s written so beautifully. But Lotje told me she while she had regained the ability to write and type after her injury, she has been left unable to read. So the whole article was written through a process of typing text and getting Siri on her iPhone to read it back to her.

The documentary is available on Netflix.
 

Link to My Beautiful Broken Brain on Wikipedia.
Link to full documentary on Netflix.
Link to long-form article in The Guardian.

Spike activity 13-05-2016

Quick links from the past week in mind and brain news:

A new paper by AI experts explores the construction of dangerous artificial intelligence. TechRepublic covers the latest step in the inevitable march towards bunker humanity.

“Brain-dead patients have served as research subjects for decades”. Interesting piece in Discover Magazine.

Neuroskeptic has started to produce videos and this is excellent: The Myth of the Brain.

There’s a crowdfunding campaign to make episode 3 of a cyberpunk / sociology of neuroscience queer porn movie. Looping effect? No, I just lost my concentration for a second.

BBC Future has an excellent piece on the hearing voices movement approach to living with hallucinated voices.

There’s an insightful piece on the changing history of names and concepts of intellectual disability in The New York Times.

The Atlantic has a sensible take on the ‘genetics of staying in school’ study and what it does, and doesn’t tell us.

Somewhat awkward title but Science News has a piece on how Bayesian approaches to cognitive science are helping us understand psychopathology.

Is there a child mental health crisis?

CC Licensed Image from Wikimedia Commons. Click for source.It is now common for media reports to mention a ‘child mental health crisis’ with claims that anxiety and depression in children are rising to catastrophic levels. The evidence behind these claims can be a little hard to track down and when you do find it there seems little evidence for a ‘crisis’ but there are still reasons for us to be concerned.

The commonest claim is something to the effect that ‘current children show a 70% increase in rates of mental illness’ and this is usually sourced to the website of the UK child mental health charity Young Minds which states that “Among teenagers, rates of depression and anxiety have increased by 70% in the past 25 years, particularly since the mid 1980’s”

This is referenced to a pdf report by the Mental Health Foundation which references a “paper presented by Dr Lynne Friedli”, which probably means this pdf report which finally references this 2004 study by epidemiologist Stephan Collishaw.

Does this study show convincing evidence for a 70% increase in teenage mental health problems in the last 25 years? In short, no, for two important reasons.

The first is that the data is quite mixed – with both flatlines and increases at different times and in different groups – and the few statistically significant results may well be false positives because the study doesn’t control for running lots of analyses.

The second reason is because it looked at a 25-year period but only up to 1999 – so it is now 17 years out-of-date.

Lots of studies have been published since then, which we’ll look at in a minute, but these findings prompted the Nuffield Foundation to collect another phase of data in 2008 in exactly the same way as this original study, and they found that “the overall level of teenage mental health problems is no longer on the increase and may even be in decline.”

Putting both these studies together, this is typical of the sort of mixed picture that is common in these studies, making it hard to say whether there genuinely is an increase in child mental health problems or not.

This is reflected in data reported by three recent review papers on the area. Two articles focused on data from rating scales – questionnaires given to parents, teachers and occasionally children, and one paper focused on population studies that use diagnosis.

The first thing to say, is that there is no stand-out clear finding that child mental health problems are increasing in general, because the results are so mixed. It’s also worth saying that even where there is evidence of an increase, the effects are small to moderate. And because there is not a lot of data, the conclusions are quite provisional.

So is there evidence for a ‘child mental health crisis’? Probably not. Are there things to be concerned about – yes, there are.

Here’s perhaps what we can make out in terms of rough trends from the data.

It doesn’t seem there is an increase in child mental health problems for young children, that is, those below about 12. If anything, their mental health has been improving over the since the early 2000s. Here, however, the data is most scarce.

Globally, and lumping all children together, there is no convincing evidence for an increase in child mental health problems. One review of rating scale data suggests there is an increase, the other paper using the more rigorous systematic review approach suggests not – in line with the data from the review of diagnostic studies.

However, there does seem to be a trend for an increase in anxiety and depression in teenage girls. And data from the UK particularly does seem to show a mild-moderate upward trend for mental health problems in adolescents in general, in comparison to other countries where the data is much more mixed. Again, though, the data isn’t as solid as it needs to be.

This leaves open some important questions though. If we’re talking about a crisis – maybe the levels were already too high so even a drop means we’re still at ‘crisis level’. So one of the most important questions is – what would be an acceptable level of mental health problems in children?

The first answer that comes to mind is ‘zero’ and not unreasonably – but considering that some mental health problems arise from largely unavoidable life stresses, bereavements, natural disasters and accidents, it would be unrealistic to expect that no child suffered periods of disabling anxiety or depression.

This also raises the question of where we decide to make the cut-off for ’emotional problems’ or ’emotional disorders’ in comparison to ‘healthy emotions’. We need anxiety, sadness and anger but they can also become disabling. Deciding where we draw the line is key in answering questions about child mental health.

So there is no way of answering the question about ‘acceptable levels of mental health problems’ without raising the question of the appropriateness of how we define problems.

Similarly, a very common finding is huge variation between countries and cultures. Concepts, reporting, and the experience of emotions can vary greatly between different cultural groups, making it difficult to make direct comparisons across the globe.

For example, the broadly Western understanding of anxiety as a distinct psychological and emotional experience which can be understood separately from its bodily effects is not one shared by many cultures.

It’s worth saying that cultural changes occur not only between peoples but also over times. Are children more likely to report emotional distress in 2016 compared to 1974 even if they feel the same? Really, we don’t know.

All of which brings us to the question- why is there so much talk about a ‘mental health crisis’ in young people if there is no strong data that there is one?

Partly this is because the mental health of children is often a way of expressing concerns about societal changes. It’s “won’t someone think of the children” given a clinical sheen. But it is also important to realise that consultations and treatment for child mental health problems have genuinely rocketed, probably because of greater awareness and better treatment.

In the UK at least, it’s also clear that talk of a ‘child mental health crisis’ can refer to two things: concerns about rising levels of mental problems, but also concerns about the ragged state of child mental health services in Britain. There is a crisis in that more children are being referred for treatment and the underfunded services are barely keeping their head above water.

So talk of a ‘crisis in rising levels of child mental health problems’ is, on balance, an exaggeration, but we shouldn’t dismiss the trends that the data do suggest.

One of the strongest is the rise in anxiety and depression in teenage girls. We clearly have a long way to go, but the world has never been safer, more equal and more full of opportunities for our soon-to-be-women. Yet there seems to be a growing minority of girls affected by anxiety and depression.

At the very least, it should make us think about whether the society we are building is appropriately supporting the future 50% of the adult population.

Spike activity 29-04-2016

Quick links from the past week in mind and brain news:

This is how it feels to learn your memories are fiction. Good BBC Future piece on confabulation from an event with the fantastic Headway East London. However, not rare as the strap line claims.

Neuroskeptic covers an interesting study on the neural precursors of spontaneous thoughts.

Who Will Debunk The Debunkers? Good FiveThirtyEight piece on why debunking memes can be myth and rumour.

Psychological Science in the Public Interest has a long, detailed impressive review article on the causes of differences in sexual orientation.

Good piece in Gizmodo on why the brain’s ‘pain matrix’ probably isn’t a ‘pain matrix’. Ignore the headline, has nothing at all to do with how pain is ‘diagnosed’.

PrimeMind has an excellent piece on the false dream of less sleep and why you can almost never win against sleep deprivation.

Science probably does advance one funeral at a time, reports Vox, covering an intriguing study.

The Atlantic reports on a new meta-analysis suggesting the harmful effects of spanking children based on correlative evidence. Should we be doing RCTs of controversial social interventions? asked Ben Goldacre last year.

The impressive ‘dictionary in the brain study’ has been fairly badly reported – lots of mention of words ‘located’ in the brain and brain area’s lighting up. Stat has a short but appropriate critique.

The search for the terrorist ‘type’

BBC World Service has an excellent radio documentary on the history and practice of terrorist profiling.

Unlike many pieces on the psychology of terrorism, which tend to take a Hollywood view of the problem, it’s an insightful, critical and genuinely enlightening piece on the false promises and possibilities of applied psychology in the service of stopping terrorists.

Crucially, it looks at how the practice developed over time and how it’s been affected by the ‘war on terror’.

For decades researchers, academics and psychologists have wanted to know what kind of person becomes a terrorist. If there are pre-existing traits which make someone more likely to kill for their beliefs – well, that would be worth knowing… It’s a story which begins decades ago. But, with the threat from killers acting for so-called Islamic State, finding an answer has never felt more pressing.

Recommended.
 
Link to programme webpage, streaming and mp3.

Spike activity 22-04-2016

Quick links from the past week in mind and brain news:

Nautilus has a fascinating piece on the science of practice and improving skills – not the same as just gaining experience.

The science behind the stoner lore of different strains of weed having distinctly different highs is taken apart by a great article in PrimeMind.

Science reports on recent findings from a cadaver study that casts doubts on whether tDCS can actually stimulate the brain at all.

Does mental illness enhance creativity? A good balanced look at the evidence from BBC Future.

Slate asks: Think Psychology’s Replication Crisis Is Bad? Welcome to the One in Medicine.

Should Therapists Write About Patients? Important personal piece published in The New York Times.

The Guardian has a brief first-person piece: The secret life of a trainee brain surgeon.

A data geek may have resurrected the much maligned field of serial killer profiling. Good piece in Boston Magazine.

A brief hallucinatory twilight

CC Licensed Photo by Flickr user Risto Kuulasmaa. Click for source.I’ve got an article in The Atlantic on the hypnagogic state – the brief hallucinatory period between wakefulness and sleep – and how it is being increasingly used as a tool to make sense of consciousness.

There is a brief time, between waking and sleep, when reality begins to warp. Rigid conscious thought starts to dissolve into the gently lapping waves of early stage dreaming and the world becomes a little more hallucinatory, your thoughts a little more untethered. Known as the hypnagogic state, it has received only erratic attention from researchers over the years, but a recent series of studies have renewed interest in this twilight period, with the hope it can reveal something fundamental about consciousness itself.

The hypnagogic state has been better dealt with by artists and writers over the years – Colderidge’s poem Kubla Khan apparently emerged out of hypnagogic reverie – albeit fuelled by opium

It has received only occasional attention from scientists, however. More recently, a spate of studies has come out showing some genuine mainstream interest in understanding hypnagogia as an interesting source of information about how consciousness is deconstructed as we enter sleep.

 

Link to article in The Atlantic on the hypnagogic state.

An echo of your former self

CC Licensed Image by Flickr user Karen Axelrad. Click for source.The journal Neurology has a brief case study reporting an intriguing form of auditory hallucination – hearing someone speaking in the voice of the last person you spoke to.

The phenomenon is called palinacousis and it usually takes the form of hallucinating an echo or repetition of the voice you’re listening to and it’s particularly associated with problems with the temporal lobes.

This case is a little different, however.

A 70-year-old right-handed white man was brought by his wife to the emergency room due to odd behavior for 2 days… According to the patient, he could not explain why people talking to him sounded strange, speaking in different voices which he heard before. For example, he would talk to a man and would hear him as talking with the voice of the woman he previously talked to. He thought it was funny and he could not concentrate on what the other person was saying because he would be laughing…

On occasion, he complained of hearing a very low-pitched intonation in people’s voices, including his own. At other times, he would hear a cyclical pattern of sounds that transitioned from noisy to silent. His most disturbing auditory symptoms persisted for several days and presented in 2 distinct forms. At first, he described hearing his deceased mother’s voice speaking to him through other people’s speech. Later on, he mentioned that after talking to one person, he would hear a second person speaking to him in the first person’s voice. He would also sometimes hear his voice as if it was the voice of the person he just spoke to. During physical therapy, the patient reported that therapist voices would suddenly change to those of people he had heard on television, which provoked uncontrollable fits of laughter.

In this case, the gentleman didn’t have damage to his temporal lobes, but a bleed that affected his right parietal lobe, which may have led to the atypical form of this hallucination.

In a recent paper, Sam Wilkinson and I noted that palinacousis is one example of an auditory hallucination that typically isn’t experienced as if you’re being communicated to by an external, illusory agent – which are perhaps the least common as most people hear hallucinated voices that appear as if they have some social characteristics.

However, it seems as if there’s even a social version of palinacousis where the echo is of someone’s voice form transposed on to the current speaker.
 

Link to PubMed entry for case study.

Spike activity 08-04-2016

Quick links from the past week in mind and brain news:

Why we’re living in an era of neuroscience hype. Excellent piece in The Daily Dot by well-known neuroscience blogger Neuroskeptic.

The Atlantic has a wonderful piece on teaching neuroscience in prison. No, not some dodgy course on ‘better living through neuroscience’ – genuine neuroscience. A great reflection on teaching science in an unlikely place.

How deep learning survived the AI winter and came to dominate cognitive computing. Great piece in re/code.

Nautilus has an interesting piece on the science of empathy in the caring professions.

My terrifying – and valuable – time in a psychiatric ward. Times Higher Educational Supplement has a piece by a US academic.

The Psychologist has an excellent piece by novelist Alex Pheby on Daniel Paul Schreber’s classic memoirs of psychosis.

The killer of Kitty Genovese dies in prison. The New York Times covers the case, the killer and the psychology myth.

Scientific American Mind asks why does the brain need so much energy?