Cognitive lives scientific

CC Licensed Image by Flickr user Charly W. Karl. Click four source.The BBC Radio 4 series The Life Scientific has recently profiled three four, count’em, three four, cognitive scientists.

Because the BBC find the internet confusing I’m just going to link straight to the mp3s to save you scrabbling about on their site.

The most recent profile you can grab as an mp3 was artificial intelligence and open data Nigel Shadbolt.

The next mp3 for your list is an interview with cognitive neuroscientist and teenage brain researcher Sarah-Jayne Blakemore.

And finally, grab the mp3 of the programme on spatial memory researcher and recent Nobel prize winner John O’Keefe.

UPDATE: Thanks to those nice folks on the Twitter who told me about another edition I missed. AI scientist Maggie Boden was also profiled and you can also grab that edition as an mp3.

That’s more than an hour an a half of pure cognitive science. Use carefully. Keep away from fire. Remember, the value of your investments may go down as well as up

Spike activity 24-04-2015

Quick links from the past week in mind and brain news:

Prospect Magazine has a good article on early psychosis and young people who hear voices.

The cost of fame. The Message discusses the nefarious social effects of fame.

Neuroskeptic asks Where Are The Big Ideas in Neuroscience?

Emotional Intelligence Doesn’t Translate Across Borders. Essential piece from the Harvard Business Review.

The New Yorker has an excellent Oliver Sacks post-traumatic brain biography of actor Spalding Gray.

Can the Static-99 save us from sex offenders? BuzzFeed has an extended article on a widely used but perhaps over-trusted risk prediction tool in forensic psychology.

Neuroconscience has an excellent piece on current big trends in neuroscience.

Ritual cannibalism occurred in England 14,700 years ago reports Science News.

A visual history of madness

The Paris Review has an extended and richly illustrated piece by historian Andrew Scull who tracks how madness has been visually depicted through the ages.

Scull is probably the most thorough and readable historian of madness since the death of the late, great Roy Porter, and this article is no exception.

Modern psychiatry seems determined to rob madness of its meanings, insisting that its depredations can be reduced to biology and nothing but biology. One must doubt it. The social and cultural dimensions of mental disorders, so indispensable a part of the story of madness and civilization over the centuries, are unlikely to melt away, or to prove no more than an epiphenomenal feature of so universal a feature of human existence. Madness indeed has its meanings, elusive and evanescent as our attempts to capture them have been.

By the way, most of the illustrations in the web article seem to be clickable for high resolution full screen versions, so you can see them in full detail.
 

Link to Madness and Meaning in Paris Review.

An instinct for fairness lurking within even the most competitive

It stings when life’s not fair – but what happens if it means we profit? As Tom Stafford writes, some people may perform unexpected self-sabotage.

Frans de Waal, a professor of primate behaviour at Emory University, is the unlikely star of a viral video. His academic’s physique, grey jumper and glasses aren’t the usual stuff of a YouTube sensation. But de Waal’s research with monkeys, and its implications for human nature, caught the imagination of millions of people.

It began with a TED talk in which de Waal showed the results of one experiment that involved paying two monkeys unequally (see video, below). Capuchin monkeys that lived together were taken to neighbouring cages and trained to hand over small stones in return for food rewards. The researchers found that a typical monkey would happily hand over stone after stone when it was rewarded for each exchange with a slice of cucumber.

But capuchin monkeys prefer grapes to cucumber slices. If the researchers paid one of the monkeys in grapes instead, the monkey in the neighbouring cage – previously happy to work for cucumber – became agitated and refused to accept payment in cucumber slices. What had once been acceptable soon became unacceptable when it was clear a neighbour was getting a better reward for the same effort.

The highlight of the video is when the poorly paid monkey throws the cucumber back at the lab assistant trying to offer it as a reward.

You don’t have to be a psychologist to know that humans can feel very much like the poorly paid monkey. Injustice stings. These results and others like them, argues de Waal, show that moral sentiments are part of our biological inheritance, a consequence of an ancestral life that was dominated by egalitarian group living – and the need for harmony between members of the group.

That’s a theory, and de Waal’s result definitely shows that our evolutionary cousins, the monkeys, are strongly influenced by social comparisons. But the experiment doesn’t really provide strong evidence that monkeys want justice. The underpaid monkey gets angry, but we’ve no evidence that the better-paid monkey is unhappy about the situation. In humans, by comparison, we can find stronger evidence that an instinct for fairness can lurk inside the psyche of even the most competitive of us.

The players in the National Basketball Association in the USA rank as some of the highest earning sportspeople in the world. In the 2007-08 season the best paid of them received salaries in excess of $20 million (£13.5 million), and more than 50 members of the league had salaries of $10 million (£6.7 million) or more.

The 2007-08 season is interesting because that is when psychologists Graeme Haynes and Thomas Gilovich reviewed recordings of more than 100 NBA games, looking for occasions that fouls were called by the referees when it was clear to the players that no foul had actually been committed. Whenever a foul is called, the wronged player gets a number of free throws – chances to score points for their team. Haynes and Gilovich were interested in how these ultra-competitive, highly paid sportsmen reacted to being awarded free throws when they knew that they didn’t really deserve them.

Missed shot

These guys had every incentive to make the most of the free throws, however unfairly gained: after all, they make their living from winning, and the points gained from free throws could settle a match. Yet Haynes and Gilovich found that players’ accuracy from unfairly awarded free throws was unusually low. It was down compared to the free throw league average, and down compared to the individual players’ free throw personal averages. Accuracy on unfairly awarded free throws was lowest when the player’s team was ahead and didn’t need the points so much. But tellingly, it was also lower than average when the team was behind and in need of points – whether honestly or dishonestly gained.

If players in one of the most competitive and best-paid sports can apparently be put off by guilt, it suggests to me that an instinct for fairness can survive even the most ruthless environments.

At the end of the monkey clip, de Waal jokes that the behaviour parallels the way people have staged protests against Wall Street, and the greed they see there. And he’s right that our discomfort with unequal pay may be as deeply set as the monkey’s.

Yet perhaps these feelings run even deeper. The analysis of the basketball players suggests that when we stand to benefit from injustices – even if they can help justify multi-million dollar salaries – some part of us is uncomfortable with the situation, and may even work to undermine that advantage.

So don’t give up on the bankers and the multi-millionaire athletes just yet.

This is my latest column for BBC Future. The original is here.

Spike activity 17-04-2015

Quick links from the past week in mind and brain news:

The latest instalment of ‘the seductive allure of neuroscience’ has been released (aka the force awakens) – a solid study suggest spurious neuroscience adds weight to explanations. Great coverage from the BPS Research Digest.

Aeon asks an interesting question: throughout evolutionary history, we never saw anything like a montage. So why do we hardly notice the cuts in movies?

There’s an excellent Motherboard documentary on the contested future of autonomous military robots you can watch online. To the bunkers!

Should I train to be a psychologist? asks The Telegraph “Clinical psychologist: pick this if you’re non-judgmental, thick-skinned and empathetic”. Cardigans, Telegraphs, you failed to mention cardigans.

Harvard Business Review has a good piece on how artificial intelligence is almost ready for business.

There’s a fascinating piece in The New York Times about how deep brain stimulation for Parkinson’s might have its effect.

Pacific Standard covers an interesting study on how school counsellors improve school performance.

Did Neurons Evolve Twice? asks Quanta Magazine. I’m not sure either of mine have common ancestors to be honest.

Narratively has a great profile of the only psychiatrist in Sadr City, Iraq.

Sex and relationship researchers write an open letter to the NSPCC to protest their use of a PR survey to claim a tenth of 12-13 year olds believe they are addicted to porn.

MIT Tech Review has a great interview on why seemingly ‘obvious’ technological interventions for poverty fail. Culture, culture, culture.

Long corridors of the mind

I’ve just read Barbara Taylor‘s brilliant book The Last Asylum: A Memoir of Madness in Our Times which blends her own experiences as a patient in one of the last remaining asylums with an incisive look at the changing face of mental health care since the Victorian era.

Taylor is a renowned historian but the book is not what you’d expect. It’s scandalous, searingly honest and often a exquisitely observed look at herself and others as they made shaky orbits around the mental health system.

Through severe mental unwellness, the state mental health system, and a searching course of psychoanalysis, Taylor is an exceptional guide and she is provides a lot of cold hard truths, as well as a lot of warm, overlooked ones.

You might think that this is a book in the same vein as Kay Redfield Jamison’s An Unquiet Mind or The Center Cannot Hold by Elyn Sacks – accounts by brilliant women who recount the challenges of developing their careers while walking on the shifting sands of the mind.

But Taylor’s book is quite different. She has become a renowned history professor but the book ends well before, when she gets her first steady job after a long period of disability. Actually, most of the book describes her dysfunction in the face of wanting to fulfil her ambitions.

In this sense, the book is more like an explorer’s journal than the post-voyage story of success. It carefully captures the day-to-day atmosphere and characters of a world she never thought she’d be in.

Wrapped around this are Taylor’s descriptions of how her experiences, and the experiences of many others like her, were situated in the mental health system of the late 20th Century. It captures the course not only of her madness, but madness as a part of a changing society.

By the way, the ‘last asylum’ in the title is the sprawling Friern Hospital née Colney Hatch Lunatic Asylum, which we’ve discussed previously on Mind Hacks as one of the many Victorian asylums which have become don’t-mention-the-past luxury flats.
 

Link to more info on The Last Asylum by Barbara Taylor.

She’s giving me hallucinations

Last year I did a talk in London on auditory hallucinations, The Beach Boys and the psychology and neuroscience of hallucinated voices, and I’ve just discovered the audio is available online.

It was part of the Pint of Science festival where they got scientists to talk about their area of research in the pub, which is exactly what I did.

The audio is hosted on SoundCloud which gives you an online stream but there’s no mp3 download facility. However, if you type the page URL into the AnythingToMP3 service it’ll present you with you an mp3 to download.

It was a fun talk, so do enjoy listening.

UPDATE: The nice folks at Pint of Science have made the mp3 downloadable directly from the SoundCloud page so no second website trickery needed.

Link to audio of Vaughan’s talk on hallucinated voices.

Spike activity 10-04-2015

Quick links from the past week in mind and brain news:

A new series of BBC Radio 4’s mind and brain magazine programme All in the Mind has just kicked off.

The New York Times has an excellent piece on America’s mental illness fuelled, jail and treatment revolving door: For Mentally Ill Inmates, a Cycle of Jail and Hospitals.

One of the few good, balanced pieces on the recent ‘genetics of sex offending’ study appeared in The Independent. Full open-access paper here if you want the original source.

MIT Tech Review reports an example of how the newly cloudified IBM AI system Watson will likely be applied more widely: focussed but free-form information provision at the human level. In this case, a museum tour guide that answers any question thrown at it.

A special documentary on Artificial Intelligence and Cinema was broadcast on BBC Radio 4. You can listen online, streamed only, because the BBC know that mp3s can kill.

New Scientist reports that a baboon bone has been found in the famous Lucy skeleton.

The pseudonymous and excellent neuroscience blogger Neuroskeptic is interviewed at Blogginheads.tv and we finally get to see his real face.

A fluctuating wellness

The New York Review of Books has an excellent new piece by Oliver Sacks where he describes the psychological effects of cancer treatment in terms of its effects on the ‘homeostasis of well being’.

The article weaves together the role of the autonomic nervous system, the progression of migraine and the repressions and releases of cancer treatment.

Indeed, everything comes and goes, and if one could take a scan or inner photograph of the body at such times, one would see vascular beds opening and closing, peristalsis accelerating or stopping, viscera squirming or tightening in spasms, secretions suddenly increasing or decreasing—as if the nervous system itself were in a state of indecision. Instability, fluctuation, and oscillation are of the essence in the unsettled state, this general feeling of disorder. We lose the normal feeling of “wellness,” which all of us, and perhaps all animals, have in health.

As you might expect it’s intricate, poetic and profound.
 

Link to ‘A General Feeling of Disorder’.

A brain of wonders

The U-T San Diego, which I originally thought was a university but turns out it’s a newspaper, has an excellent online multimedia project called ‘The Wonders of Your Brain’ which is an extensive and excellent look at some of the key issues in modern neuroscience.

It tackles everything from the development of the brain from embryo to old age, how the brain processes senses, the challenges of neurosurgery, mental health and brain disorders, and the future of brain science – to name just a little of the content.

It has some great articles, fantastic video, and includes a range of neuroscientists discussing their work.

Specialist science magazines would be proud to have this as a neuroscience piece so good work U-T San Diego. I may never have heard of you but apparently your a proper newspaper and you do great online neuroscience specials.

Recommended.
 

Link to ‘The Wonders of Your Brain’.

How is the brain relevant in mental disorder?

The Psychologist has a fascinating article on how neuroscience fits in to our understanding of mental illness and what practical benefit brain science has – in lieu of the fact that it currently doesn’t really help us a great deal in the clinic.

It is full of useful ways of thinking about how neuroscience fits into our view of mental distress.

The following is a really crucial section, that talks about the difference between proximal (closer) and distal (more distant) causes.

In essence, rather than talking about causes we’re probably better off talking about causal pathways – chains of events that can lead to a problem – which can include common elements but different people can arrive at the same difficulty in different ways.

A useful notion is to consider different types of causes of symptoms lying on a spectrum, the extremes of which I will term ‘proximal’ and ‘distal’. Proximal causes are directly related to the mechanisms driving symptoms, and are useful targets for treatment; they are often identified through basic science research. For example, lung cancer is (proximally) caused by malfunction in the machinery that regulates cell division. Traditional lung cancer treatments tackle this cause by removing the malfunctioning cells (surgery) or killing them (standard chemotherapy and radiotherapy)…

By contrast, distal causes are indirectly related to the mechanisms driving symptoms, and are useful targets for prevention; they are often identified through epidemiology research. Again, take the example of lung cancer, which is (distally) caused by cigarette smoking in the majority of cases, though it must be caused by other factors in people who have never smoked. These could be genetic (lung cancer is heritable), other types of environmental trigger (e.g. radon gas exposure) or some interaction between the two. Given the overwhelming evidence that lung cancer is (distally) caused by smoking, efforts at prevention rightly focus on reducing its incidence. However, after a tumour has developed an oncologist must focus on the proximal cause when proposing a course of treatment…

The majority of studies of depression have focused on distal causes (which psychologists might consider ‘underlying’). These include: heritability and genetics; hormonal and immune factors; upbringing and early life experience; and personality. More proximal causes include: various forms of stress, particularly social; high-level psychological constructs derived from cognitive theories (e.g. dysfunctional negative schemata); low-level constructs such as negative information processing biases (also important in anxiety); and disrupted transmission in neurotransmitter systems such as serotonin.

It’s not a light read, but it is well worth diving into it for a more in-depth treatment of the brain and mental illness.
 

Link to Psychologist article neuroscience and mental health.

Mind Hacks excerpts x 2

This month, Business Insider have republished a couple of chapters from Mind Hacks the book (in case you missed it, back before the blog, Mind Hacks was a book, 101 do-it-at-home psychology experiences). The excerpts are:

1. Why one of these puzzles is easy and the other is hard – which is about the Wason Selection Task, a famous example of how our ability to reason logically can be confounded (and unconfounded if you find the right format to present a problem in).

2. Why this sentence is hard to understand – which shows you how to improve your writing with a bit of elementary psychology (hint: it is about reducing working memory load). Steven Pinker covers the same advice in his new book The Sense of Style (2014).

Both excerpts show off some of the neat illustrations done for the book, as well as being a personal nostalgia trip for yours truly (it’s been ten years!)

Links: Why this sentence is hard to understand + Why one of these puzzles is easy and the other is hard

Trauma is more complex than we think

I’ve got an article in The Observer about how the official definition of trauma keeps changing and how the concept is discussed as if it were entirely intuitive and clear-cut, when it’s actually much more complex.

I’ve become fascinated by how the concept of ‘trauma’ is used in public debate about mental health and the tension that arises between the clinical and rhetorical meanings of trauma.

One unresolved issue, which tests mental health professionals to this day, is whether ‘traumatic’ should be defined in terms of events or reactions.

Some of the confusion arises when we talk about “being traumatised”. Let’s take a typically horrifying experience – being caught in a war zone as a civilian. This is often described as a traumatic experience, but we know that most people who experience the horrors of war won’t develop post-traumatic stress disorder or PTSD – the diagnosis designed to capture the modern meaning of trauma. Despite the fact that these sorts of awful experiences increase the chances of acquiring a range of mental health problems – depression is actually a more common outcome than PTSD – it is still the case that most people won’t develop them. Have you experienced trauma if you have no recognisable “scar in the psyche”? This is where the concept starts to become fuzzy.

We have the official diagnosis of posttraumatic stress disorder or PTSD but actually lots of mental health problems can appear after awful events, and yet there is no ‘posttraumatic depression’ or ‘posttraumatic social phobia’ diagnoses.

To be clear, it’s not that trauma doesn’t exist but that it’s less fully developed as a concept than people think and, as a result, often over-simplified during debates.

Full article at the link below.
 

Link to Observer article on the shifting sands of trauma.

Spike activity 06-03-2015

Quick links from the past week in mind and brain news:

The strange world of felt presences. Great piece in The Guardian.

Nature reports that the Human Brain Project has voted for a change of leadership. But read carefully, it’s not clear how much will change in practice.

Surely the worst ‘neuroscience of’ article ever written? “The Neuroscience of ISIS” from The Daily Beast. Ruthlessly, it’s the first in a series.

Project Syndicate on why social science needs to be on the front-line of the fight against drug-resistant diseases.

Psychiatry is More Complex than Either its Proponents or its Critics Seem Able to Admit. Insightful piece on Mental Health Chat.

iDigitalTimes on what DeepMind’s computer game playing AI tells us where artificial intelligence falls short.

No link found between psychosis and use of ‘classic’ psychedelics LSD, psilocybin and mescaline in two large studies, reports Nature.

Beautiful online exhibition of the work of surreal optical illusion photographer Erik Johansson over at Twisted Sifter.

Radical embodied cognition: an interview with Andrew Wilson

adw_headshot_squareThe computational approach is the orthodoxy in psychological science. We try and understand the mind using the metaphors of information processing and the storage and retrieval of representations. These ideas are so common that it is easy to forget that there is any alternative. Andrew Wilson is on a mission to remind us that there is an alternative – a radical, non-representational, non-information processing take on what cognition is.

I sent him a few questions by email. After he answered these, and some follow up questions, we’ve both edited and agreed on the result, which you can read below.

 

Q1. Is it fair to say you are at odds with lots of psychology, theoretically? Can you outline why?

Psychology wants to understand what causes our behaviour. Cognitive psychology explanations are that behaviour is caused by internal states of the mind (or brain, if you like). These states are called mental representations, and they are models/simulations of the world that we use to figure out what to do and when to do it.

Cognitive psychology thinks we have representations because it assumes we have very poor sensory access to the world, e.g. vision supposedly begins with a patchy 2D image projected onto the back of the eye. We need these models to literally fill in the gaps by making an educated guess (‘inference’) about what caused those visual sensations.

My approach is called radical embodied cognitive psychology; ‘radical’ just means ‘no representations’. It is based on the work of James J Gibson. He was a perceptual psychologist who demonstrated that there is actually rich perceptual information about the world, and that we use this information. This is why perception and action are so amazingly successful most of the time, which is important because failures of perception have serious consequences for your health and wellbeing (e.g. falling on ice)

The most important consequence of this discovery is that when we have access to this information, we don’t need those internal models anymore. This then means that whatever the brain is doing, it’s not building models of the world in order to cause our behaviour. We are embedded in our environments and our behaviour is caused by the nature of that embedding (specifically, which information variables we are using for any given task).

So I ask very different questions than the typical psychologist: instead of ‘what mental model lets me solve this task?’ I ask ‘what information is there to support the observed behaviour and can I find evidence that we use it?’. When we get the right answer to the information question, we have great success in explaining and then predicting behaviour, which is actually the goal of psychology.

 

Q2. The idea that there are no mental representations is hard to get your head around. What about situations where behaviour seems to be based on things which aren’t there, like imagination, illusions or predictions?

First, saying that there are no mental representations is not saying that the brain is not up to something. This is a surprisingly common mistake, but I think it’s due to the fact cognitive psychologists have come to equate ‘brain activity’ with ‘representing’ and denying the latter means denying the former (see Is Embodied Cognition a No-Brainer?).

Illusions simply reveal how important it is to perception that we can move and explore. They are all based on a trick and they almost always require an Evil Psychologist™ lurking in the background. Specifically, illusions artificially restrict access to information so that the world looks like it’s doing one thing when it is really doing another. They only work if you don’t let people do anything to reveal the trick. Most visual illusions are revealed as such by exploring them, e.g by looking at them from a different perspective (e.g. the Ames Room).

Imagination and prediction are harder to talk about in this framework, but only because no one’s really tried. For what it’s worth, people are terrible at actively predicting things, and whatever imagination is it will be a side-effect of our ability to engage with the real world, not part of how we engage with the real world.

 

Q3. Is this radical approach really denying the reality of cognitive representations, or just using a different descriptive language in which they don’t figure? In other words, can you and the cognitivists both be right?

If the radical hypothesis is right, then a lot of cognitive theories will be wrong. Those theories all assume that information comes into the brain, is processed by representations and then output as behaviour. If we successfully replace representations with information, all those theories will be telling the wrong story. ‘Interacting with information’ is a completely different job description for the brain than ‘building models of the world’. This is another reason why it’s ‘radical’.

 

Q4. Even if I concede that you can think of the mind like this, can you convince me that I should? Why is it useful? What does this approach do for cognitive science that the conventional approach isn’t or cant’?

There are two reasons, I think. The first is empirical; this approach works very, very well. Whenever a researcher works through a problem using this approach, they find robust answers that stand up to extended scrutiny in the lab. These solutions then make novel predictions that also perform well  – examples are topics like the outfielder problem and the A-not-B error [see below for references]. Cognitive psychology is filled with small, difficult to replicate effects; this is actually a hint that we aren’t asking the right questions. Radical embodied cognitive science tends to produce large, robust and interpretable effects which I take as a hint that our questions are closer to the mark.

The second is theoretical. The major problem with representations is that it’s not clear where they get their content from. Representations supposedly encode knowledge about the world that we use to make inferences to support perception, etc. But if we have such poor perceptual contact with the world that we need representations, how did we ever get access to the knowledge we needed to encode? This grounding problem is a disaster. Radical embodiment solves it by never creating it in the first place – we are in excellent perceptual contact with our environments, so there are no gaps for representations to fill, therefore no representations that need content.

 

Q5. Who should we be reading to get an idea of this approach?

‘Beyond the Brain’ by Louise Barrett. It’s accessible and full of great stuff.

‘Radical Embodied Cognitive Science’ by Tony Chemero. It’s clear and well written but it’s pitched at trained scientists more than the generally interested lay person.

‘Embodied Cognition’ by Lawrence Shapiro that clearly lays out all the various flavours of ‘embodied cognition’. My work is the ‘replacement’ hypothesis.

‘The Ecological Approach to Visual Perception’ by James J Gibson is an absolute masterpiece and the culmination of all his empirical and theoretical work.

I run a blog at http://psychsciencenotes.blogspot.co.uk/ with Sabrina Golonka where we discuss all this a lot, and we tweet @PsychScientists. We’ve also published a few papers on this, the most relevant of which is ‘Embodied Cognition is Not What You Think It Is

 

Q6. And finally, can you point us to a few blog posts you’re proudest of which illustrate this way of looking at the world

What Else Could It Be? (where Sabrina looks at the question, what if the brain is not a computer?)

Mirror neurons, or, What’s the matter with neuroscience? (how the traditional model can get you into trouble)

Prospective Control – The Outfielder problem (an example of the kind of research questions we ask)

Fluctuating existence

The Neurologist has a fascinating case report of a women with Parkinson’s disease who experienced a fluctuating belief that she didn’t exist.

Cotard’s delusion is usually described as the ‘belief that you’re dead’ although Jules Cotard, for whom the delusion is named, defined it as a délire des négations – the delusion of negation, or nihilism, as it’s usually translated.

In fact, in his original case report, Cotard’s patient didn’t believe they were dead but that they had “no brain, nerves, chest, or entrails, and was just skin and bone”.

This new case report in The Neurologist describes a patient with Parkinson’s disease who experiences something similar with the delusion appearing as their Parkinson’s medication began to wear off.

In December 2010, she went to follow-up visit accompanied by her caregivers and they reported that, in the last 2 months, the patient has developed a sudden onset of nihilistic delusion, mainly during the “wearing-off” condition and associated with end of dose dyskinesias and akathisia. The patient repeatedly complained of having lost both of her eyes, mouth, nose, and ears. Often during these events, she insisted to have a mirror to see herself. She expressed the false belief that she did not have the whole body and that nothing existed, including herself, without any insight. This nihilistic delusion, compatible with the diagnosis of Cotard syndrome, clearly improved with the administration of the following dose of levodopa and the associated amelioration of motor symptoms.

This is interesting because the Parkinson’s medication – levodopa – is a precursor to dopamine and is used to increase dopamine levels in the brain.

Increased dopamine levels in mid-brain areas are considered to be a key causal factor in generating the delusions and hallucinations of psychosis, but in this case delusions reliably appeared as dopamine levels were likely to have been dropping due to the medication wearing off.

Although this is a single case study, the effect was reliable when repeated, but it doesn’t mean that this would happen with everybody in the same situation.

But what it really shows is that the neurobiology of psychosis is not a simple ‘chemical imbalance’ but, in part, a complex dysregulation that can effect individuals differently due to the inherent interconnectedness of neural systems.
 

Link to PubMed entry for case report.

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