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	<title>Comments on: The straight dopamine theory could be up in smoke</title>
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	<description>Neuroscience and psychology news and views.</description>
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		<title>By: Rand</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-50578</link>
		<dc:creator><![CDATA[Rand]]></dc:creator>
		<pubDate>Mon, 11 Feb 2013 00:46:52 +0000</pubDate>
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		<description><![CDATA[It has been my experience that dopamine antagonists can effect how marijuana is processed.  I started taking a dopamine antagonist in 2006.  From 2006 thru 2010 marijuana had a profound effect on me, so much that I stayed away from it.  The last 3 years however I have not been able to get high no matter how much I smoke or eat.

I&#039;ve gone through periods in my life where I was a daily marijuana smoker mixed with years of not smoking at all.  I&#039;d say over the last 25 years I was a daily smoker for 7 years.  I can&#039;t say that marijuana has contributed to my paranoid delusions or not.  Personally, I think having used ecstasy 10 times, one time injecting meth and a couple times smoking weed laced with god knows what was far more damaging than all those years of smoking marijuana.  I do know that I was drinking myself sick once a week while I was in the Navy.  I finally said that enough was enough and started growing/smoking weed everyday.  I have never had a problem with alcohol since.

I miss getting stoned.  I really hope that I&#039;ll be able to sometime in the future again, but that is looking like less and less of a possibility.  I got off the dopamine antagonist for a couple of months a couple months ago.  After two months, I still couldn&#039;t get high.  My sex drive was back to normal, I was eating normally again and my head was clear so working was a real pleasure.  I did wind up hearing voices and ended up in the hospital again though.

The only upside I see is that I can eat as much food with marijuana in it as I want.  Tasty!  No really, I&#039;ve had some really good food with it in it.]]></description>
		<content:encoded><![CDATA[<p>It has been my experience that dopamine antagonists can effect how marijuana is processed.  I started taking a dopamine antagonist in 2006.  From 2006 thru 2010 marijuana had a profound effect on me, so much that I stayed away from it.  The last 3 years however I have not been able to get high no matter how much I smoke or eat.</p>
<p>I&#8217;ve gone through periods in my life where I was a daily marijuana smoker mixed with years of not smoking at all.  I&#8217;d say over the last 25 years I was a daily smoker for 7 years.  I can&#8217;t say that marijuana has contributed to my paranoid delusions or not.  Personally, I think having used ecstasy 10 times, one time injecting meth and a couple times smoking weed laced with god knows what was far more damaging than all those years of smoking marijuana.  I do know that I was drinking myself sick once a week while I was in the Navy.  I finally said that enough was enough and started growing/smoking weed everyday.  I have never had a problem with alcohol since.</p>
<p>I miss getting stoned.  I really hope that I&#8217;ll be able to sometime in the future again, but that is looking like less and less of a possibility.  I got off the dopamine antagonist for a couple of months a couple months ago.  After two months, I still couldn&#8217;t get high.  My sex drive was back to normal, I was eating normally again and my head was clear so working was a real pleasure.  I did wind up hearing voices and ended up in the hospital again though.</p>
<p>The only upside I see is that I can eat as much food with marijuana in it as I want.  Tasty!  No really, I&#8217;ve had some really good food with it in it.</p>
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	<item>
		<title>By: Patty</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-27088</link>
		<dc:creator><![CDATA[Patty]]></dc:creator>
		<pubDate>Sun, 13 May 2012 22:43:29 +0000</pubDate>
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		<description><![CDATA[The discussion over cannabis is way too abstract. The fact is every strain is different. It&#039;s not like alcohol where the only difference is the amount of alcohol in each type of booze. With cannabis each strain is a completely different drug that can attach to either serotonin, dopamine or acetylcholine. Cannabis for autism is a good idea but not until people learn what the hell they&#039;re talking about should they just abitrarily assume all pot is indicated for autism.]]></description>
		<content:encoded><![CDATA[<p>The discussion over cannabis is way too abstract. The fact is every strain is different. It&#8217;s not like alcohol where the only difference is the amount of alcohol in each type of booze. With cannabis each strain is a completely different drug that can attach to either serotonin, dopamine or acetylcholine. Cannabis for autism is a good idea but not until people learn what the hell they&#8217;re talking about should they just abitrarily assume all pot is indicated for autism.</p>
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		<title>By: Danny T</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-24944</link>
		<dc:creator><![CDATA[Danny T]]></dc:creator>
		<pubDate>Thu, 05 Jan 2012 19:49:55 +0000</pubDate>
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		<description><![CDATA[Im pretty sure cannabis lowers levels of dopamine the same way an anti-psychotic would BUT when the levels are too low for extended periods of time, the brain will increase the natural amount of dopamine created to make up for the lack of, to restore balance to the individuals natural chemical levels.]]></description>
		<content:encoded><![CDATA[<p>Im pretty sure cannabis lowers levels of dopamine the same way an anti-psychotic would BUT when the levels are too low for extended periods of time, the brain will increase the natural amount of dopamine created to make up for the lack of, to restore balance to the individuals natural chemical levels.</p>
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		<title>By: Cannabis for Autism</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-20481</link>
		<dc:creator><![CDATA[Cannabis for Autism]]></dc:creator>
		<pubDate>Tue, 12 Jul 2011 16:46:44 +0000</pubDate>
		<guid isPermaLink="false">http://mindhacksblog.wordpress.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-20481</guid>
		<description><![CDATA[http://www.ukcia.org/research/keele_study/Assessing-the-impact-of-cannabis.pdf

&quot;
A recent systematic review concluded that cannabis use increases risk of psychotic outcomes
independently of confounding and transient intoxication effects. Furthermore, a model of the
association between cannabis use and schizophrenia indicated that the incidence and
prevalence of schizophrenia would increase from 1990 onwards. The model is based on three
factors: a) increased relative risk of psychotic outcomes for frequent cannabis users compared
to those who have never used cannabis between 1.8 and 3.1, b) a substantial rise in UK cannabis
use from the mid-1970s and c) elevated risk of 20 years from ﬁrst use of cannabis. This paper
investigates whether this has occurred in the UK by examining trends in the annual prevalence
and incidence of schizophrenia and psychoses, as measured by diagnosed cases from 1996 to
2005. Retrospective analysis of the General Practice Research Database (GPRD) was conducted
for 183 practices in England, Wales, Scotland and Northern Ireland. The study cohort comprised
almost 600,000 patients each year, representing approximately 2.3% of the UK population aged
16 to 44. Between 1996 and 2005 the incidence and prevalence of schizophrenia and psychoses
were either stable or declining. Explanations other than a genuine stability or decline were
considered, but appeared less plausible. In conclusion, this study did not ﬁnd any evidence of
increasing schizophrenia or psychoses in the general population from 1996 to 2005&quot;

There you go. Cannabis does not cause any extra cases of Schizophrenia when you actually bother to look for them.

As ever, show me the bodies, then I might see you in court.]]></description>
		<content:encoded><![CDATA[<p><a href="http://www.ukcia.org/research/keele_study/Assessing-the-impact-of-cannabis.pdf" rel="nofollow">http://www.ukcia.org/research/keele_study/Assessing-the-impact-of-cannabis.pdf</a></p>
<p>&#8221;<br />
A recent systematic review concluded that cannabis use increases risk of psychotic outcomes<br />
independently of confounding and transient intoxication effects. Furthermore, a model of the<br />
association between cannabis use and schizophrenia indicated that the incidence and<br />
prevalence of schizophrenia would increase from 1990 onwards. The model is based on three<br />
factors: a) increased relative risk of psychotic outcomes for frequent cannabis users compared<br />
to those who have never used cannabis between 1.8 and 3.1, b) a substantial rise in UK cannabis<br />
use from the mid-1970s and c) elevated risk of 20 years from ﬁrst use of cannabis. This paper<br />
investigates whether this has occurred in the UK by examining trends in the annual prevalence<br />
and incidence of schizophrenia and psychoses, as measured by diagnosed cases from 1996 to<br />
2005. Retrospective analysis of the General Practice Research Database (GPRD) was conducted<br />
for 183 practices in England, Wales, Scotland and Northern Ireland. The study cohort comprised<br />
almost 600,000 patients each year, representing approximately 2.3% of the UK population aged<br />
16 to 44. Between 1996 and 2005 the incidence and prevalence of schizophrenia and psychoses<br />
were either stable or declining. Explanations other than a genuine stability or decline were<br />
considered, but appeared less plausible. In conclusion, this study did not ﬁnd any evidence of<br />
increasing schizophrenia or psychoses in the general population from 1996 to 2005&#8243;</p>
<p>There you go. Cannabis does not cause any extra cases of Schizophrenia when you actually bother to look for them.</p>
<p>As ever, show me the bodies, then I might see you in court.</p>
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		<title>By: David</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-19540</link>
		<dc:creator><![CDATA[David]]></dc:creator>
		<pubDate>Thu, 12 May 2011 01:26:54 +0000</pubDate>
		<guid isPermaLink="false">http://mindhacksblog.wordpress.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-19540</guid>
		<description><![CDATA[Are you trying to prove it&#039;s bad???  Never hurt anyone I know, too late in the evening to get technical on an iPod]]></description>
		<content:encoded><![CDATA[<p>Are you trying to prove it&#8217;s bad???  Never hurt anyone I know, too late in the evening to get technical on an iPod</p>
]]></content:encoded>
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		<title>By: Wag</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-8825</link>
		<dc:creator><![CDATA[Wag]]></dc:creator>
		<pubDate>Thu, 12 Aug 2010 23:43:26 +0000</pubDate>
		<guid isPermaLink="false">http://mindhacksblog.wordpress.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-8825</guid>
		<description><![CDATA[@Yezizhang the problem with making statements such as this, is that there really are no conclusive studies to support the view that Marijuana causes schizophrenia. Even the most biased government anti-drug campaign funded studies are only reporting a small increased risk for developing schizophrenia. That is well within their margin of error, as they have no way of knowing if the test subjects (which aren&#039;t even human) were already developing schizophrenia before the cannabis was administered. 

In the USA barely 1% of the population at any given time is diagnosed with schizophrenia. According to NIDA (US drug war propaganda think tank), up to 50% of US 12th graders in 1997 had used Marijuana. If there was any actual connection between marijuana and mental disorder, we would have an epidemic on our hands.  
http://drugabuse.gov/ResearchReports/Marijuana/default.html
At best, modern psychology is guesswork. We throw compounds at the brain and analyze the results. What&#039;s worse, people have wildly variable response to the same compound. Our FDA will approve drugs that have clear risk of death as a side-effect and place a drug such as marijuana on Schedule I (no medicinal value, illegal) that is, at best, tenuously connected to schizophrenia. Even the most biased sources (NIDA, Drug Czar) have not used the &quot;schizophrenia connection&quot; in many years here in the USA. If there was any real science behind the idea, they would use it. In fact, recent studies further discredit it.
http://www.ncbi.nlm.nih.gov/pubmed/20471224]]></description>
		<content:encoded><![CDATA[<p>@Yezizhang the problem with making statements such as this, is that there really are no conclusive studies to support the view that Marijuana causes schizophrenia. Even the most biased government anti-drug campaign funded studies are only reporting a small increased risk for developing schizophrenia. That is well within their margin of error, as they have no way of knowing if the test subjects (which aren&#8217;t even human) were already developing schizophrenia before the cannabis was administered. </p>
<p>In the USA barely 1% of the population at any given time is diagnosed with schizophrenia. According to NIDA (US drug war propaganda think tank), up to 50% of US 12th graders in 1997 had used Marijuana. If there was any actual connection between marijuana and mental disorder, we would have an epidemic on our hands.<br />
<a href="http://drugabuse.gov/ResearchReports/Marijuana/default.html" rel="nofollow">http://drugabuse.gov/ResearchReports/Marijuana/default.html</a><br />
At best, modern psychology is guesswork. We throw compounds at the brain and analyze the results. What&#8217;s worse, people have wildly variable response to the same compound. Our FDA will approve drugs that have clear risk of death as a side-effect and place a drug such as marijuana on Schedule I (no medicinal value, illegal) that is, at best, tenuously connected to schizophrenia. Even the most biased sources (NIDA, Drug Czar) have not used the &#8220;schizophrenia connection&#8221; in many years here in the USA. If there was any real science behind the idea, they would use it. In fact, recent studies further discredit it.<br />
<a href="http://www.ncbi.nlm.nih.gov/pubmed/20471224" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/20471224</a></p>
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		<title>By: Yezizhang</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-5549</link>
		<dc:creator><![CDATA[Yezizhang]]></dc:creator>
		<pubDate>Mon, 28 Jun 2010 04:24:27 +0000</pubDate>
		<guid isPermaLink="false">http://mindhacksblog.wordpress.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-5549</guid>
		<description><![CDATA[Neurocritic
the results from the Phase 2 clinical trial with LY2140023 (a glutamate agonist) were disheartening.  Because there was barely any efficacy for LY2140023 they have to do more Phase 2 trials.  They were heavily dissapointed with the results
]]></description>
		<content:encoded><![CDATA[<p>Neurocritic<br />
the results from the Phase 2 clinical trial with LY2140023 (a glutamate agonist) were disheartening.  Because there was barely any efficacy for LY2140023 they have to do more Phase 2 trials.  They were heavily dissapointed with the results</p>
]]></content:encoded>
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		<title>By: Yezizhang</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-5548</link>
		<dc:creator><![CDATA[Yezizhang]]></dc:creator>
		<pubDate>Mon, 28 Jun 2010 04:19:49 +0000</pubDate>
		<guid isPermaLink="false">http://mindhacksblog.wordpress.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-5548</guid>
		<description><![CDATA[CarlLuma-
http://www.nida.nih.gov/Infofacts/marijuana.html
http://www.nimh.nih.gov/health/publications/schizophrenia/complete-index.shtml
http://www.theantidrug.com/drug-information/marijuana-facts/marijuana-mental-health.aspx
http://www.medpagetoday.com/Psychiatry/Addictions/18722
And many, many more studies.  Just search Google Scholar or any medical journal sites.
I would know, heavy marijuana use precipitated my schizophrenia.
]]></description>
		<content:encoded><![CDATA[<p>CarlLuma-<br />
<a href="http://www.nida.nih.gov/Infofacts/marijuana.html" rel="nofollow">http://www.nida.nih.gov/Infofacts/marijuana.html</a><br />
<a href="http://www.nimh.nih.gov/health/publications/schizophrenia/complete-index.shtml" rel="nofollow">http://www.nimh.nih.gov/health/publications/schizophrenia/complete-index.shtml</a><br />
<a href="http://www.theantidrug.com/drug-information/marijuana-facts/marijuana-mental-health.aspx" rel="nofollow">http://www.theantidrug.com/drug-information/marijuana-facts/marijuana-mental-health.aspx</a><br />
<a href="http://www.medpagetoday.com/Psychiatry/Addictions/18722" rel="nofollow">http://www.medpagetoday.com/Psychiatry/Addictions/18722</a><br />
And many, many more studies.  Just search Google Scholar or any medical journal sites.<br />
I would know, heavy marijuana use precipitated my schizophrenia.</p>
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	<item>
		<title>By: Yezizhang</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-5547</link>
		<dc:creator><![CDATA[Yezizhang]]></dc:creator>
		<pubDate>Mon, 28 Jun 2010 04:11:01 +0000</pubDate>
		<guid isPermaLink="false">http://mindhacksblog.wordpress.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-5547</guid>
		<description><![CDATA[Animals don&#039;t like pot?  Just type in cat eating pot in youtube.  I grew medical marijuana for a clinic and I had a cat that LOVED to eat the leaves.  My stepdad used to grow it in his backyard and his cat would love to nibble on the plants.  Where did you hear that animals don&#039;t like cannabis?
]]></description>
		<content:encoded><![CDATA[<p>Animals don&#8217;t like pot?  Just type in cat eating pot in youtube.  I grew medical marijuana for a clinic and I had a cat that LOVED to eat the leaves.  My stepdad used to grow it in his backyard and his cat would love to nibble on the plants.  Where did you hear that animals don&#8217;t like cannabis?</p>
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	<item>
		<title>By: Richard N</title>
		<link>http://mindhacks.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-5546</link>
		<dc:creator><![CDATA[Richard N]]></dc:creator>
		<pubDate>Wed, 29 Jul 2009 19:47:45 +0000</pubDate>
		<guid isPermaLink="false">http://mindhacksblog.wordpress.com/2009/06/28/the-straight-dopamine-theory-could-be-up-in-smoke/#comment-5546</guid>
		<description><![CDATA[Hey Neuroskeptic--
I trained dope smelling dogs for the Border Patrol and, well... dogs LOVE pot. You feed them, on average, about 1/4 oz. per day in their food. Yes, they get a tad weird, and yes, they &#039;nap&#039; a lot.
Do they &quot;like it&quot;... oh, yes. They will tear a car to pieces if they smell any. The hardest part is to keep them from eating the evidence when they find it. Typically we would abstain from feeding any pot for 2 days before they went to the field to work. While dogs can be trained to find drugs without &quot;sampling&quot; them, the ones who have been stoned are a great deal more effective.
During this training period I also noticed that my two house-cats were very interested in pot and would also eat it, happily. But being cats, it was hard to tell if they liked it. Sure did seem to.
]]></description>
		<content:encoded><![CDATA[<p>Hey Neuroskeptic&#8211;<br />
I trained dope smelling dogs for the Border Patrol and, well&#8230; dogs LOVE pot. You feed them, on average, about 1/4 oz. per day in their food. Yes, they get a tad weird, and yes, they &#8216;nap&#8217; a lot.<br />
Do they &#8220;like it&#8221;&#8230; oh, yes. They will tear a car to pieces if they smell any. The hardest part is to keep them from eating the evidence when they find it. Typically we would abstain from feeding any pot for 2 days before they went to the field to work. While dogs can be trained to find drugs without &#8220;sampling&#8221; them, the ones who have been stoned are a great deal more effective.<br />
During this training period I also noticed that my two house-cats were very interested in pot and would also eat it, happily. But being cats, it was hard to tell if they liked it. Sure did seem to.</p>
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