http://mindhacks.com/2005/12/08/a-problem-with-placebo-controlled-trials/ Neuroscience and psychology news and views. Fri, 17 May 2013 22:36:12 +0000 hourly 1 http://wordpress.com/ http://mindhacks.com/2005/12/08/a-problem-with-placebo-controlled-trials/#comment-8154 Fri, 09 Dec 2005 10:33:05 +0000 http://mindhacksblog.wordpress.com/2005/12/08/a-problem-with-placebo-controlled-trials/#comment-8154 hi tom
yeh, he basically said that the placebo effect in trials for the banned drugs was larger than it had been in the trials demonstrating the efficacy of fluoxetine. i don’t have any more detail on that unfortunately. he also said that for other conditions where efficacy of ssri’s had been demonstrated (e.g. OCD), the placebo effect had been smaller there too. so you end up with a weird situation: drugs for conditions (like OCD) that are less responsive to placebo effects, don’t have to demonstrate as great an impact on symptoms (to be deemed effective), compared with drugs being tested for conditions ilke depression, that are highly responsive to placebo effects.

]]> http://mindhacks.com/2005/12/08/a-problem-with-placebo-controlled-trials/#comment-8153 Fri, 09 Dec 2005 10:13:30 +0000 http://mindhacksblog.wordpress.com/2005/12/08/a-problem-with-placebo-controlled-trials/#comment-8153 Really interesting. Presumably you could look at the original papers and see how big the placebo effect was? Some variation in the size of placebo effect would be expected – is Dr Santosh suggesting that there is systemmatic variation between different drug trials?

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